Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690355 | 0.87 | GAA (0.40) | SSTR5KDM4EMEN1KMT2A | |
| SCHEMBL5118350 | 0.87 | POLB (0.42) | SSTR5KDM4EMEN1CYP2C9ALOX15 | |
| SCHEMBL5124004 | 0.84 | HCRTR1 (0.42) | SSTR5KDM4EALOX15 | |
| SCHEMBL689686 | 0.81 | SSTR5 (0.42) | SSTR5PARP1PARP2KDM4EMEN1 | |
| SCHEMBL689162 | 0.79 | SSTR5 (0.41) | SSTR5KDM4EMEN1KMT2A | |
| SCHEMBL5119234 | 0.77 | SCN9A (0.43) | CYP2C19KDM4EMEN1ALOX15TSHR | |
| SCHEMBL689665 | 0.75 | MAPT (0.41) | KDM4EMEN1KMT2A | |
| SCHEMBL690226 | 0.75 | ALDH1A1 (0.43) | SSTR5KDM4EMEN1KMT2A | |
| SCHEMBL5114802 | 0.74 | SCN9A (0.46) | SLC9A1 | |
| SCHEMBL690623 | 0.73 | RARG (0.41) | PARP1PARP2KDM4EMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |