Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Methanesulfonamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100B | P04271 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | GFER | P55789 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL7955346 | 0.95 | S100B (0.80) | S100BALDH1A1MEN1KMT2AL3MBTL1 | |
| Methanesulfonamide SCHEMBL793229 | 0.95 | S100B (0.80) | S100BALDH1A1MEN1KMT2AL3MBTL1 | |
| Sulfuric Acid SCHEMBL9131658 | 0.87 | S100B (0.62) | S100BALDH1A1MEN1KMT2AL3MBTL1 | |
| Sulfuric Acid SCHEMBL10371487 | 0.85 | S100B (0.64) | S100BALDH1A1MEN1KMT2AL3MBTL1 | |
| Sulfuric Acid SCHEMBL10582678 | 0.85 | S100B (0.64) | S100BALDH1A1MEN1KMT2AL3MBTL1 | |
| Sulfuric Acid SCHEMBL9566805 | 0.85 | S100B (0.64) | S100BALDH1A1MEN1KMT2AL3MBTL1 | |
| Sulfuric Acid SCHEMBL2140481 | 0.85 | S100B (0.64) | S100BALDH1A1MEN1KMT2AL3MBTL1 | |
| Sulfuric Acid SCHEMBL10945925 | 0.85 | S100B (0.64) | S100BALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL34104 | 0.85 | S100B (1.00) | S100BALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL29350181 | 0.85 | S100B (1.00) | S100BALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380893-A2 | Colour photographic print material | Agfa-Gevaert (BE) | 2004-01-14 | — | — | EP | disclosed |
| US-5360700-A | Single stabilizing step, magenta and cyan couplers, ferric salt of organic acid | KONICA CORPORATION (JP) | 1994-11-01 | — | — | US | disclosed |
| EP-0255785-A2 | Silver halide photographic light-sensitive material excellent in treatment stability | KONICA CORPORATION (JP) | 1988-02-10 | — | — | EP | disclosed |
| US-4138257-A | BROMINE OR IODINE IONS AS FIXATIVE, PYRROLIDONE POLYMER | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1979-02-06 | — | — | US | disclosed |