Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894814 | 0.93 | MAPT (0.44) | MAPTALDH1A1GAAPKMPLA2G2A | |
| SCHEMBL6888047 | 0.91 | CNR1 (0.38) | MAPTALDH1A1GAAPKMMEN1 | |
| SCHEMBL6892160 | 0.91 | PLA2G2A (0.44) | MAPTALDH1A1GAAPKMPLA2G2A | |
| SCHEMBL6898378 | 0.90 | ACMSD (0.39) | MAPTALDH1A1GAAPKMPLA2G2A | |
| SCHEMBL6897303 | 0.90 | PLA2G2A (0.42) | MAPTALDH1A1GAAPKMPLA2G2A | |
| SCHEMBL6897168 | 0.90 | PLA2G1B (0.44) | MAPTALDH1A1GAAPKMPLA2G2A | |
| SCHEMBL6894729 | 0.90 | MAPT (0.41) | MAPTALDH1A1GAAPKMPLA2G2A | |
| SCHEMBL6896777 | 0.89 | FAAH (0.44) | MAPTALDH1A1GAAPKMTHRB | |
| SCHEMBL6777282 | 0.89 | PLA2G2A (0.41) | PLA2G2A | |
| SCHEMBL6889689 | 0.88 | MAPT (0.47) | MAPTALDH1A1GAAPKMTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |