Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.44 |
| ▸ | CCR8 | P51685 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691213 | 0.92 | FAAH (0.46) | FAAHCCR8ALDH1A1KDM4ETDP1 | |
| SCHEMBL6894814 | 0.92 | MAPT (0.44) | ALDH1A1KDM4EMAPTTHRBGAA | |
| SCHEMBL6896220 | 0.91 | FAAH (0.43) | FAAHCCR8ALDH1A1KDM4EMAPT | |
| SCHEMBL6894773 | 0.91 | FAAH (0.43) | FAAHCCR8ALDH1A1KDM4EMAPT | |
| SCHEMBL6897075 | 0.91 | CETP (0.41) | FAAHCCR8ALDH1A1 | |
| SCHEMBL6775435 | 0.90 | PLA2G2A (0.40) | FAAHCCR8ALDH1A1KDM4ETDP1 | |
| SCHEMBL6897434 | 0.89 | MAPT (0.39) | ALDH1A1KDM4EMAPTTHRBGAA | |
| SCHEMBL6897303 | 0.89 | PLA2G2A (0.42) | FAAHALDH1A1MAPTTHRBGAA | |
| SCHEMBL6892310 | 0.89 | FAAH (0.41) | FAAHCCR8ALDH1A1MAPTTP53 | |
| SCHEMBL6888939 | 0.87 | TSPO (0.42) | KDM4ETDP1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |