Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 6/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 3/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6901404 | 0.86 | FAAH (0.36) | FAAHALDH1A1MAPTCA2MMP8 | |
| SCHEMBL6897175 | 0.85 | FAAH (0.35) | FAAHALDH1A1MAPTCA2MMP8 | |
| SCHEMBL6892029 | 0.76 | FAAH (0.34) | FAAHALDH1A1MAPTCA2MMP8 | |
| SCHEMBL6901774 | 0.76 | ALDH1A1 (0.41) | FAAHALDH1A1MAPTCA2MMP8 | |
| SCHEMBL6897513 | 0.76 | FAAH (0.34) | FAAHALDH1A1MAPTCA2MMP8 | |
| SCHEMBL7122564 | 0.74 | FAAH (0.48) | FAAHALDH1A1CA2THRB | |
| SCHEMBL10722736 | 0.74 | FAAH (0.48) | FAAHALDH1A1CA2THRB | |
| SCHEMBL10721831 | 0.74 | FAAH (0.48) | FAAHALDH1A1CA2THRB | |
| SCHEMBL11213670 | 0.73 | FAAH (0.35) | FAAHALDH1A1MAPTCA2MMP8 | |
| SCHEMBL6897804 | 0.72 | FAAH (0.41) | FAAHALDH1A1MAPTCA2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6734311-B2 | ANTIINFLAMMATORY AGENTS; ALZHEIMER'S DISEASE; CARDIOVASCULAR DISORDERS | MERCK & CO., INC. | 2004-05-11 | — | — | US | disclosed |
| US-20030092746-A1 | Substituted amidine derivatives as inhibitors of cell adhesion | MERCK & CO., INC. | 2003-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092746-A1 | Substituted amidine derivatives as inhibitors of cell adhesion | VCAM1, CD4, ICAM1 | FAAH 795/4885ALDH1A1 663/4885MAPT 527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.