Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.38 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6899031 | 0.82 | PDE10A (0.41) | PDE10AMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6900338 | 0.76 | MAPT (0.49) | PDE10AMAPTL3MBTL1SMN1; SMN2PDE1B | |
| SCHEMBL1836435 | 0.66 | AURKA (0.49) | PDE10AMAPTL3MBTL1SMN1; SMN2PDE1B | |
| SCHEMBL28463716 | 0.63 | RAB9A (0.48) | MAPTL3MBTL1PIK3CAALDH1A1RAB9A | |
| SCHEMBL27821490 | 0.63 | MAPT (0.43) | PDE10AMAPTL3MBTL1SMN1; SMN2PDE1B | |
| SCHEMBL8851946 | 0.62 | RAB9A (0.50) | PDE10AMAPTL3MBTL1KDM4EPIK3CA | |
| SCHEMBL10663061 | 0.62 | PDE10A (0.49) | PDE10AMAPTL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL24476642 | 0.62 | DCTPP1 (0.52) | MAPTL3MBTL1SMN1; SMN2PDE1BPDE1A | |
| SCHEMBL8851150 | 0.62 | PDE10A (0.48) | PDE10AMAPTL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL5755331 | 0.61 | SMN1; SMN2 (1.00) | MAPTSMN1; SMN2KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8828990-B2 | N-7 substituted purine and pyrazolopyrimine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2014-09-09 | — | — | US | disclosed |
| US-20110086840-A1 | N-7 SUBSTITUTED PURINE AND PYRAZOLOPYRIMINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086840-A1 | N-7 SUBSTITUTED PURINE AND PYRAZOLOPYRIMINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | P2RX7, P2RY1, PNP | PDE10A 341/4885MAPT 4237/4885L3MBTL1 3516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.