Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | OGG1 | O15527 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23279339 | 0.85 | ALOX5 (0.42) | ALOX5MEN1KMT2AIDO1CES2 | |
| SCHEMBL10735461 | 0.82 | LMNA (0.41) | MEN1KMT2ACA1CA2KDM4E | |
| SCHEMBL6690812 | 0.80 | LMNA (0.42) | KMT2AIDO1CES2CES1SMN1; SMN2 | |
| SCHEMBL11581937 | 0.80 | KCNN4 (0.39) | KMT2AIDO1CES2CES1NQO2 | |
| SCHEMBL11581649 | 0.80 | TPMT (0.35) | CA1CA2SLC22A2SLC22A1SLC22A3 | |
| SCHEMBL3077185 | 0.80 | ALOX5 (0.42) | ALOX5MEN1KMT2AIDO1CES2 | |
| SCHEMBL6691676 | 0.79 | NPFFR1 (0.31) | CA1CA2 | |
| SCHEMBL3073692 | 0.79 | ALDH1A1 (0.45) | ALOX5MEN1KMT2APLAUALDH1A1 | |
| SCHEMBL6898137 | 0.78 | C1S (0.46) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL28482173 | 0.78 | ALDH1A1 (0.43) | ALOX5MEN1KMT2AIDO1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888141-B1 | FILM-FORMING COMPOSITIONS OF ANTIHYPERALGESIC OPIATES AND THEIR USE FOR TREATING HYPERALGESIC CONDITIONS THEREWITH | ADOLOR CORP (US) | 2004-05-26 | — | — | EP | claimed |
| US-6353004-B1 | TREATMENT OF PRUTITIC CONDITION IN VAGINA | ADOLOR COPORATION | 2002-03-05 | — | — | US | claimed |
| EP-0888141-A4 | FILM-FORMING COMPOSITIONS OF ANTIHYPERALGESIC OPIATES AND METHOD OF TREATING HYPERALGESIC CONDITIONS THEREWITH | ADOLOR CORP (US) | 2001-01-17 | — | — | EP | claimed |
| EP-0888141-A1 | FILM-FORMING COMPOSITIONS OF ANTIHYPERALGESIC OPIATES AND METHOD OF TREATING HYPERALGESIC CONDITIONS THEREWITH | Adolor Corporation (US) | 1999-01-07 | — | — | EP | claimed |
| US-5849762-A | Peripherally acting anti-pruritic opiates | ADOLOR CORPORATION (US) | 1998-12-15 | — | — | US | claimed |
| WO-1997033634-A1 | FILM-FORMING COMPOSITIONS OF ANTIHYPERALGESIC OPIATES AND METHOD OF TREATING HYPERALGESIC CONDITIONS THEREWITH | ADOLOR CORPORATION (US) | 1997-09-18 | — | — | WO | claimed |
| US-5667773-A | Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith | ADOLOR CORPORATION (US) | 1997-09-16 | — | — | US | claimed |
| US-4025652-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1977-05-24 | — | — | US | claimed |
| EP-0888141-B1 | FILM-FORMING COMPOSITIONS OF ANTIHYPERALGESIC OPIATES AND THEIR USE FOR TREATING HYPERALGESIC CONDITIONS THEREWITH | ADOLOR CORP (US) | 2004-05-26 | — | — | EP | disclosed |
| US-6576650-B1 | No central nervous system side effects | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-06-10 | — | — | US | disclosed |
| US-6573282-B1 | Compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors | ADOLOR CORPORATION | 2003-06-03 | — | — | US | disclosed |
| US-6353004-B1 | TREATMENT OF PRUTITIC CONDITION IN VAGINA | ADOLOR COPORATION | 2002-03-05 | — | — | US | disclosed |
| US-6166039-A | Peripherally active anti-hyperalgesic opiates | REGENTS OF THE UNIV. OF CALIFORNIA (US) | 2000-12-26 | — | — | US | disclosed |
| US-5994372-A | ANTIDIARRHEA COMPOUND | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0086193-A1 | THE TREATMENT AND PREVENTION OF SCOURS IN ANIMALS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1983-08-24 | — | — | EP | disclosed |
| EP-0073276-A1 | A method of increasing the feed efficiency of animals, and compositions for use in such a method | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1983-03-09 | — | — | EP | disclosed |
| WO-1983000626-A1 | THE TREATMENT AND PREVENTION OF SCOURS IN ANIMALS | RORER INT OVERSEAS (US) | 1983-03-03 | — | — | WO | disclosed |
| US-4340609-A | Amidinourea derivative veterinary compositions for suppression of parasitemia | WILLIAM H. RORER, INC. (US) | 1982-07-20 | — | — | US | disclosed |
| US-4285972-A | Method of treating scours | WILLIAM H. RORER, INC. (US) | 1981-08-25 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |