Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10735461 | 0.82 | LMNA (0.41) | LMNANPC1ALDH1A1ALOX15MAPT | |
| SCHEMBL11581649 | 0.80 | TPMT (0.35) | CA1CA2 | |
| SCHEMBL11581937 | 0.80 | KCNN4 (0.39) | IDO1ALDH1A1IKBKBCES2CES1 | |
| SCHEMBL6899079 | 0.80 | ALOX5 (0.41) | LMNAIDO1ALDH1A1CES2CES1 | |
| SCHEMBL3077185 | 0.80 | ALOX5 (0.42) | LMNAIDO1ALDH1A1CES2CES1 | |
| SCHEMBL6695957 | 0.79 | IDO1 (0.38) | IDO1ALDH1A1HTR3EHTR3BHTR3A | |
| SCHEMBL3073692 | 0.79 | ALDH1A1 (0.45) | NPC1ALDH1A1POLBTDP1CYP2C19 | |
| SCHEMBL6694312 | 0.79 | ALDH1A1 (0.42) | LMNANPC1IDO1ALDH1A1HTR3E | |
| SCHEMBL6892243 | 0.78 | HTR3E (0.60) | LMNAIDO1ALDH1A1HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL28482173 | 0.78 | ALDH1A1 (0.43) | NPC1IDO1ALDH1A1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3553083-B2 | — | — | 2004-08-11 | — | — | JP | claimed |
| EP-0888141-B1 | FILM-FORMING COMPOSITIONS OF ANTIHYPERALGESIC OPIATES AND THEIR USE FOR TREATING HYPERALGESIC CONDITIONS THEREWITH | ADOLOR CORP (US) | 2004-05-26 | — | — | EP | claimed |
| US-6353004-B1 | TREATMENT OF PRUTITIC CONDITION IN VAGINA | ADOLOR COPORATION | 2002-03-05 | — | — | US | claimed |
| US-5849762-A | Peripherally acting anti-pruritic opiates | ADOLOR CORPORATION (US) | 1998-12-15 | — | — | US | claimed |
| EP-0852494-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-07-15 | — | — | EP | claimed |
| US-5667773-A | Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith | ADOLOR CORPORATION (US) | 1997-09-16 | — | — | US | claimed |
| WO-1997009973-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-03-20 | — | — | WO | claimed |
| US-4446152-A | SUBSTITUTED PHENYLAMIDINOUREA | WILLIAM H. RORER, INC. (US) | 1984-05-01 | — | — | US | claimed |
| US-4025652-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1977-05-24 | — | — | US | claimed |
| EP-0888141-B1 | FILM-FORMING COMPOSITIONS OF ANTIHYPERALGESIC OPIATES AND THEIR USE FOR TREATING HYPERALGESIC CONDITIONS THEREWITH | ADOLOR CORP (US) | 2004-05-26 | — | — | EP | disclosed |
| US-6576650-B1 | No central nervous system side effects | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-06-10 | — | — | US | disclosed |
| US-6573282-B1 | Compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors | ADOLOR CORPORATION | 2003-06-03 | — | — | US | disclosed |
| US-6353004-B1 | TREATMENT OF PRUTITIC CONDITION IN VAGINA | ADOLOR COPORATION | 2002-03-05 | — | — | US | disclosed |
| EP-0888141-A4 | FILM-FORMING COMPOSITIONS OF ANTIHYPERALGESIC OPIATES AND METHOD OF TREATING HYPERALGESIC CONDITIONS THEREWITH | ADOLOR CORP (US) | 2001-01-17 | — | — | EP | disclosed |
| EP-0086193-A1 | THE TREATMENT AND PREVENTION OF SCOURS IN ANIMALS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1983-08-24 | — | — | EP | disclosed |
| EP-0073276-A1 | A method of increasing the feed efficiency of animals, and compositions for use in such a method | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1983-03-09 | — | — | EP | disclosed |
| WO-1983000626-A1 | THE TREATMENT AND PREVENTION OF SCOURS IN ANIMALS | RORER INT OVERSEAS (US) | 1983-03-03 | — | — | WO | disclosed |
| US-4340609-A | Amidinourea derivative veterinary compositions for suppression of parasitemia | WILLIAM H. RORER, INC. (US) | 1982-07-20 | — | — | US | disclosed |
| US-4285972-A | Method of treating scours | WILLIAM H. RORER, INC. (US) | 1981-08-25 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |