Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691084 | 0.93 | PTK2 (0.47) | PTK2KDM4CPOLBALDH1A1KDM4E | |
| SCHEMBL691573 | 0.91 | MAPK1 (0.50) | PTK2KDM4CMEN1KMT2APOLB | |
| SCHEMBL691296 | 0.90 | PTK2 (0.56) | PTK2KDM4CMEN1KMT2AALDH1A1 | |
| SCHEMBL691390 | 0.85 | PTK2 (0.46) | PTK2KDM4CKDM4ESMN1; SMN2MAPK3 | |
| SCHEMBL691543 | 0.83 | PTK2 (0.60) | PTK2KDM4CPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL689984 | 0.83 | PTK2 (0.64) | PTK2KDM4CMEN1KMT2APOLB | |
| SCHEMBL691211 | 0.82 | PTK2 (0.44) | PTK2KDM4CMEN1KMT2AALDH1A1 | |
| SCHEMBL691652 | 0.82 | PTK2 (0.57) | PTK2MEN1KMT2AUSP2MAPK3 | |
| SCHEMBL691659 | 0.81 | PTK2 (0.59) | PTK2MAPK3MAPK1KCNH2 | |
| SCHEMBL690575 | 0.80 | PTK2 (0.58) | PTK2KDM4CMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421537-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010062578-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-06-03 | — | — | WO | disclosed |