Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 4/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689985 | 0.93 | PTK2 (0.45) | PTK2KDM4CNPC1LMNARAB9A | |
| SCHEMBL691390 | 0.91 | PTK2 (0.46) | PTK2KDM4CLMNASMN1; SMN2DHODH | |
| SCHEMBL691296 | 0.90 | PTK2 (0.56) | PTK2KDM4CLMNAALDH1A1HPGD | |
| SCHEMBL691543 | 0.89 | PTK2 (0.60) | PTK2KDM4CNPC1LMNARAB9A | |
| SCHEMBL691573 | 0.85 | MAPK1 (0.50) | PTK2KDM4CLMNASMN1; SMN2POLB | |
| SCHEMBL691083 | 0.83 | PTK2 (0.66) | PTK2DHODHFABP3FABP4KDM4E | |
| SCHEMBL691659 | 0.83 | PTK2 (0.59) | PTK2MAPK3MAPK1 | |
| SCHEMBL691211 | 0.82 | PTK2 (0.44) | PTK2KDM4CALDH1A1MAPK3MAPK1 | |
| SCHEMBL691652 | 0.82 | PTK2 (0.57) | PTK2LMNAHPGDMAPK3MAPK1 | |
| SCHEMBL690218 | 0.82 | PTK2 (0.58) | PTK2ALDH1A1HPGDMAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421537-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010062578-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-06-03 | — | — | WO | disclosed |