Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 5/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.58 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.58 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | NNMT | P40261 | 2/20 | 0.58 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.58 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.58 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.58 |
| ▸ | INMT | O95050 | 1/20 | 0.58 |
| ▸ | NSD2 | O96028 | 1/20 | 0.58 |
| ▸ | PNMT | P11086 | 1/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.58 |
| ▸ | HNMT | P50135 | 1/20 | 0.58 |
| ▸ | WDR5 | P61964 | 1/20 | 0.58 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6900339 | 1.00 | AHCY (0.60) | AHCYHIF1ATMEM97SIGMAR1DOT1L | |
| SCHEMBL2118345 | 0.85 | AHCY (0.61) | AHCYDOT1LKMT2APRMT5WDR77 | |
| SCHEMBL14696726 | 0.84 | PRKACA (0.61) | AHCYHIF1ATMEM97SIGMAR1DOT1L | |
| SCHEMBL4191285 | 0.83 | AHCY (0.59) | AHCYDOT1LKMT2APRMT5WDR77 | |
| SCHEMBL14696483 | 0.83 | PRKACA (0.65) | AHCYHIF1ATMEM97SIGMAR1DOT1L | |
| SCHEMBL14696395 | 0.83 | PRKACA (0.65) | AHCYHIF1ATMEM97SIGMAR1DOT1L | |
| SCHEMBL101380 | 0.82 | AHCY (0.62) | AHCYHIF1ATMEM97SIGMAR1DOT1L | |
| SCHEMBL29385449 | 0.82 | AHCY (0.68) | AHCYHIF1ATMEM97SIGMAR1DOT1L | |
| SCHEMBL2117335 | 0.82 | AHCY (0.68) | AHCYHIF1ATMEM97SIGMAR1DOT1L | |
| SCHEMBL1757011 | 0.82 | AHCY (0.68) | AHCYHIF1ATMEM97SIGMAR1DOT1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482977-A1 | COMBINATION THERAPIES FOR TREATING METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS | PFIZER INC. (US) | 2004-12-08 | — | — | EP | disclosed |
| US-20040043959-A1 | Combination therapies for treating methylthioadenosine phosphorylase deficient cells | AGOURON PHARMACEUTICALS INC. | 2004-03-04 | — | — | US | disclosed |
| WO-2003074083-A1 | COMBINATION THERAPIES FOR TREATING METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS | PFIZER INC. (US) | 2003-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043959-A1 | Combination therapies for treating methylthioadenosine phosphorylase deficient cells | APRT, MTAP, TYMP | AHCY 62/4885HIF1A 3905/4885TMEM97 4737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.