Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13832673 | 0.74 | ALDH1A1 (0.31) | MAPT | |
| SCHEMBL14391510 | 0.73 | MAOB (0.35) | ACHEMAPTTDP1 | |
| SCHEMBL14879098 | 0.71 | HPGD (0.44) | ACHEMAPTTDP1 | |
| SCHEMBL8684748 | 0.69 | ACHE (0.44) | ACHEMAPTTDP1HTR2AHTR2C | |
| SCHEMBL7246061 | 0.68 | KDM1A (0.35) | HTR2AHTR2CHTR2B | |
| SCHEMBL14201547 | 0.68 | RET (0.32) | — | |
| SCHEMBL6521233 | 0.68 | ACHE (0.42) | ACHEMAPTTDP1HTR2AHTR2C | |
| SCHEMBL18855128 | 0.67 | — | — | |
| SCHEMBL14642171 | 0.65 | MAPT (0.34) | ACHEMAPTTDP1HTR2AHTR2C | |
| SCHEMBL8639636 | 0.64 | GABRP (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011030068-A1 | USE OF INDOLE DERIVATIVES AS NURR-1 ACTIVATORS FOR THE APPLICATION THEREOF AS A MEDICAMENT FOR THE TREATMENT OF PARKINSON'S DISEASE | LABORATOIRES FOURNIER SA (FR) | 2011-03-17 | — | — | WO | disclosed |