Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | STAT3 | P40763 | 6/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 4/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | PEAK1 | Q9H792 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | F13A1 | P00488 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | TGM1 | P22735 | 1/20 | 0.38 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1874183 | 0.82 | F13A1 (0.59) | HTTSMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL28322311 | 0.70 | MEN1 (0.64) | MEN1STAT3NR2F2HRH1HTR2C | |
| SCHEMBL6901071 | 0.69 | TGM2 (0.59) | LMNAF13A1TGM2TGM1TGM3 | |
| SCHEMBL6901428 | 0.69 | LMNA (0.48) | HTTSMN1; SMN2MAPTNPC1L3MBTL1 | |
| SCHEMBL14276917 | 0.68 | HTT (0.63) | MEN1STAT3NR2F2HRH1HTR2C | |
| SCHEMBL28322310 | 0.68 | MEN1 (0.64) | MEN1STAT3NR2F2HRH1HTR2C | |
| SCHEMBL6899848 | 0.68 | TGM2 (0.62) | LMNAF13A1TGM2TGM1TGM3 | |
| SCHEMBL12789895 | 0.67 | MEN1 (0.71) | MEN1STAT3NR2F2HRH1HTR2C | |
| SCHEMBL6901350 | 0.67 | HTR1A (0.49) | HTR2CF13A1TGM2TGM1TGM3 | |
| SCHEMBL6901841 | 0.67 | F13A1 (0.59) | F13A1TGM2TGM1TGM3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011060321-A1 | TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2011-05-19 | — | — | WO | disclosed |