Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 12/20 | 0.47 |
| ▸ | F13A1 | P00488 | 5/20 | 0.46 |
| ▸ | TGM1 | P22735 | 5/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6901071 | 0.80 | TGM2 (0.59) | LMNATGM2F13A1TGM1TGM3 | |
| SCHEMBL6899848 | 0.79 | TGM2 (0.62) | LMNATGM2F13A1TGM1TGM3 | |
| SCHEMBL6902507 | 0.77 | TGM2 (0.65) | MAPTTGM2F13A1TGM1TGM3 | |
| SCHEMBL6900600 | 0.76 | TGM2 (0.46) | LMNATGM2F13A1TGM1THRA | |
| SCHEMBL1867975 | 0.76 | F13A1 (0.72) | TGM2F13A1TGM1TGM3 | |
| SCHEMBL6902596 | 0.75 | TGM2 (0.68) | TGM2F13A1TGM1TGM3 | |
| SCHEMBL6901614 | 0.75 | TGM2 (0.48) | LMNARAB9AMAPTSMN1; SMN2TGM2 | |
| SCHEMBL9559810 | 0.72 | EGFR (0.51) | LMNARAB9AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL6901811 | 0.72 | F13A1 (0.72) | TGM2F13A1TGM1TGM3 | |
| SCHEMBL6900590 | 0.72 | TGM2 (0.54) | TGM2F13A1TGM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011060321-A1 | TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2011-05-19 | — | — | WO | disclosed |