Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 10/20 | 0.45 |
| ▸ | CNR2 | P34972 | 10/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9290267 | 0.87 | CNR1 (0.45) | CNR1CNR2ALDH1A1MAPK14SSTR5 | |
| SCHEMBL690623 | 0.83 | RARG (0.41) | ALDH1A1L3MBTL1 | |
| SCHEMBL12727200 | 0.82 | CNR1 (0.43) | CNR1CNR2ALDH1A1MAPK14SSTR5 | |
| SCHEMBL690167 | 0.82 | MAPT (0.38) | ALDH1A1MAPK14RAB9AL3MBTL1 | |
| SCHEMBL1599294 | 0.80 | ALDH1A1 (0.48) | CNR1CNR2ALDH1A1MAPK14RAB9A | |
| SCHEMBL690108 | 0.80 | ALOX5 (0.39) | ALDH1A1 | |
| SCHEMBL690830 | 0.78 | LMNA (0.42) | ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL690703 | 0.74 | KDM4E (0.46) | ALDH1A1MAPK14 | |
| SCHEMBL1404705 | 0.74 | RARG (0.38) | ALDH1A1L3MBTL1 | |
| SCHEMBL13977760 | 0.73 | ALDH1A1 (0.67) | ALDH1A1RAB9AL3MBTL1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |