Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.41 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690623 | 0.85 | RARG (0.41) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL690167 | 0.84 | MAPT (0.38) | MEN1KMT2AEPHX2NR1H4MAPT | |
| SCHEMBL690108 | 0.82 | ALOX5 (0.39) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL1847649 | 0.80 | GSK3A (0.42) | LMNANR5A2NR5A1MEN1KMT2A | |
| SCHEMBL14155437 | 0.79 | POLB (0.43) | LMNANR5A2NR5A1MEN1KMT2A | |
| SCHEMBL689596 | 0.78 | CNR1 (0.45) | ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL689916 | 0.77 | ALDH1A1 (0.44) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL1404705 | 0.76 | RARG (0.38) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL689665 | 0.75 | MAPT (0.41) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL690317 | 0.75 | RARG (0.36) | MEN1KMT2AEPHX2NR1H4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |