Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 4/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689916 | 0.90 | ALDH1A1 (0.44) | GSK3AMAPK14SRCSYKALDH1A1 | |
| SCHEMBL16106403 | 0.84 | GSK3A (0.43) | GSK3AMAPK14SRCSYKALDH1A1 | |
| SCHEMBL692574 | 0.84 | GSK3A (0.41) | GSK3AMAPK14SRCSYKALDH1A1 | |
| SCHEMBL692947 | 0.81 | HTT (0.42) | LMNAGSK3AMAPK14SRCSYK | |
| SCHEMBL690109 | 0.79 | SCARB1 (0.44) | GSK3AMAPK14SRCSYKALDH1A1 | |
| SCHEMBL690623 | 0.79 | RARG (0.41) | GSK3AALDH1A1MEN1HTTKMT2A | |
| SCHEMBL690703 | 0.79 | KDM4E (0.46) | GSK3AMAPK14ALDH1A1KDM4E | |
| SCHEMBL690666 | 0.77 | GSK3A (0.37) | GSK3AMAPK14SRCSYKALDH1A1 | |
| SCHEMBL690060 | 0.76 | MAPK14 (0.53) | MAPK14SCARB1 | |
| SCHEMBL690766 | 0.75 | GSK3A (0.36) | GSK3AMAPK14SRCSYKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |