Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 17/20 | 0.46 |
| ▸ | F13A1 | P00488 | 11/20 | 0.46 |
| ▸ | TGM1 | P22735 | 11/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1864419 | 0.80 | TGM2 (0.68) | TGM2F13A1TGM1 | |
| SCHEMBL6901428 | 0.76 | LMNA (0.48) | TGM2F13A1TGM1LMNATGM3 | |
| SCHEMBL6901071 | 0.74 | TGM2 (0.59) | TGM2F13A1TGM1LMNATGM3 | |
| SCHEMBL6899848 | 0.71 | TGM2 (0.62) | TGM2F13A1TGM1LMNATGM3 | |
| SCHEMBL6902881 | 0.70 | TGM2 (0.69) | TGM2F13A1TGM1 | |
| SCHEMBL6902507 | 0.70 | TGM2 (0.65) | TGM2F13A1TGM1TGM3 | |
| SCHEMBL6901614 | 0.70 | TGM2 (0.48) | TGM2F13A1TGM1LMNA | |
| SCHEMBL23507518 | 0.68 | ALDH1A1 (0.58) | LMNABRD4 | |
| SCHEMBL22820605 | 0.68 | TGM2 (0.59) | TGM2F13A1TGM1LMNATGM3 | |
| SCHEMBL24742677 | 0.68 | TEAD1 (0.47) | TGM2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011060321-A1 | TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2011-05-19 | — | — | WO | disclosed |