Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | F13A1 | P00488 | 5/20 | 0.48 |
| ▸ | TGM1 | P22735 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6902596 | 0.83 | TGM2 (0.68) | TGM2F13A1TGM1 | |
| SCHEMBL6901658 | 0.81 | KDM4E (0.55) | KDM4EMEN1KMT2AHRH3TPSAB1 | |
| SCHEMBL1871008 | 0.80 | TGM2 (0.71) | TGM2F13A1TGM1KMT2A | |
| SCHEMBL6901826 | 0.77 | KDM4E (0.51) | KDM4EMEN1KMT2AHRH3TPSAB1 | |
| SCHEMBL6899848 | 0.76 | TGM2 (0.62) | TGM2F13A1TGM1LMNA | |
| SCHEMBL6900590 | 0.76 | TGM2 (0.54) | TGM2F13A1TGM1KMT2A | |
| SCHEMBL6901428 | 0.75 | LMNA (0.48) | TGM2F13A1TGM1TP53NPC1 | |
| SCHEMBL6901711 | 0.74 | F13A1 (0.53) | TGM2F13A1TGM1 | |
| SCHEMBL6901811 | 0.73 | F13A1 (0.72) | TGM2F13A1TGM1 | |
| SCHEMBL11775423 | 0.73 | TGM2 (0.71) | TGM2F13A1TGM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011060321-A1 | TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2011-05-19 | — | — | WO | disclosed |