Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR known ✓ | P25105 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6904393 | 0.89 | PTAFR (0.31) | PTAFR | |
| Hydrochloric Acid SCHEMBL6903745 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL6901840 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL6902655 | 0.84 | HSD17B1 (0.31) | HSD17B1HSD17B2ALOX5ACKR3 | |
| Hydrochloric Acid SCHEMBL6903286 | 0.84 | PTAFR (0.31) | PTAFRHSD17B1HSD17B2ALOX5ACKR3 | |
| Hydrochloric Acid SCHEMBL6903464 | 0.81 | NQO2 (0.35) | — | |
| Hydrochloric Acid SCHEMBL6903459 | 0.79 | TRPV1 (0.39) | PTAFR | |
| Hydrochloric Acid SCHEMBL5607408 | 0.77 | KIF11 (0.33) | PTAFR | |
| Hydrochloric Acid SCHEMBL6897986 | 0.76 | BRD4 (0.31) | — | |
| Hydrochloric Acid SCHEMBL5607325 | 0.74 | BRD4 (0.32) | PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |