Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15456512 | 0.74 | ABCB11 (0.40) | ABCB11 | |
| SCHEMBL417479 | 0.68 | — | — | |
| SCHEMBL16307089 | 0.68 | ABCB11 (0.43) | ABCB11 | |
| SCHEMBL5922493 | 0.68 | ABCB11 (0.43) | ABCB11 | |
| SCHEMBL5144441 | 0.68 | ALOX15 (0.31) | — | |
| SCHEMBL16692501 | 0.67 | ABCB11 (0.35) | ABCB11 | |
| SCHEMBL6135586 | 0.67 | MAPT (0.39) | ABCB11 | |
| SCHEMBL6673904 | 0.66 | ABCB11 (0.47) | ABCB11 | |
| SCHEMBL3858792 | 0.66 | ABCB11 (0.44) | ABCB11 | |
| SCHEMBL3858793 | 0.66 | ABCB11 (0.44) | ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436290-A1 | ALKYNE-ARYL-NAPHTHYRIDIN-4(1H)-0NE DERIVATIVES AS TYPE IV PHOSPHODIESTERASE INHIBITOR | Merck Frosst Canada & Co. (CA) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003018579-A1 | ALKYNE-ARYL PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2003-03-06 | — | — | WO | disclosed |