Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL28291481 | 0.95 | ALDH1A1 (0.73) | — | |
| Hydrochloric Acid SCHEMBL16292352 | 0.95 | ALDH1A1 (0.73) | — | |
| Hydrochloric Acid SCHEMBL20447685 | 0.95 | — | — | |
| Tetrahydrofuran SCHEMBL1005228 | 0.95 | ALDH1A1 (0.89) | — | |
| Tetrahydrofuran SCHEMBL27261732 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL1539228 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL1450115 | 0.90 | ALDH1A1 (0.80) | — | |
| Tetrahydrofuran SCHEMBL18729662 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL732690 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL22230565 | 0.90 | ALDH1A1 (0.80) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944726-B2 | Solid catalyst component, catalyst comprising said solid component, and process for the (co)polymerization of α-olefins | VERSALIS S.P.A. (IT) | 2018-04-17 | — | — | US | claimed |
| CN-103314017-B | The catalyst of ingredient of solid catalyst including the solid constituent and for alhpa olefin（Altogether）The method of polymerization | 维尔萨利斯股份公司 | 2017-07-18 | — | — | CN | claimed |
| US-20160060370-A1 | SOLID CATALYST COMPONENT, CATALYST COMPRISING SAID SOLID COMPONENT, AND PROCESS FOR THE (CO)POLYMERIZATION OF ALPHA-OLEFINS | VERSALIS S.P.A. (IT) | 2016-03-03 | — | — | US | claimed |
| US-20130303360-A1 | SOLID CATALYST COMPONENT, CATALYST COMPRISING SAID SOLID COMPONENT, AND PROCESS FOR THE (CO)POLYMERIZATION OF ALPHA-OLEFINS | VERSALIS S.P.A. (IT) | 2013-11-14 | — | — | US | claimed |
| CN-118290620-A | Supported late transition metal catalyst and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-116730812-A | Preparation method of 4,4' -difluorobenzophenone | 武汉瑞阳化工有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-112174788-B | Preparation method of 2, 6-tetraethyl-3, 5-heptane dione | 浙江凯普化工有限公司 | 2023-06-20 | — | — | CN | disclosed |
| CN-113087832-B | Method for synthesizing polyolefin by using coal-made alpha-olefin and product | 中国科学院上海有机化学研究所 | 2023-01-31 | — | — | CN | disclosed |
| CN-115611769-A | Method and device for synthesizing sartanbiphenyl by continuous flow | 赛诺威(厦门)科技有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-114105737-A | Preparation method and application of intermediate of abamectin A | 重庆华邦胜凯制药有限公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-113087823-A | Catalyst containing fluoroalcohol load and preparation method and application thereof | 中国科学院上海有机化学研究所 | 2021-07-09 | — | — | CN | disclosed |
| CN-113087832-A | Method for synthesizing polyolefin by using coal-made alpha-olefin and product | 中国科学院上海有机化学研究所 | 2021-07-09 | — | — | CN | disclosed |
| EP-2658885-A1 | SOLID CATALYST COMPONENT, CATALYST COMPRISING SAID SOLID COMPONENT, AND PROCESS FOR THE (CO)POLYMERIZATION OF ALPHA-OLEFINS | versalis S.p.A. (IT) | 2013-11-06 | — | — | EP | disclosed |
| CN-103314017-A | Solid catalyst component, catalyst comprising said solid component, and process for the (co)polymerization of alpha-olefins | POLIMERI EUROPA SPA | 2013-09-18 | — | — | CN | disclosed |
| WO-2012089562-A1 | SOLID CATALYST COMPONENT, CATALYST COMPRISING SAID SOLID COMPONENT, AND PROCESS FOR THE (CO)POLYMERIZATION OF ALPHA-OLEFINS | POLIMERI EUROPA S.P.A. (IT) | 2012-07-05 | — | — | WO | disclosed |
| CN-1239520-C | Composite magnesium carrier and ethene polymerization solid catalyst constituent therefrom | CHINA PETROCHEMICAL CORP (CN) | 2006-02-01 | — | — | CN | disclosed |
| EP-0878484-B1 | A process for the preparation of a megnesium halide supported metallocene catalyst | COUNCIL SCIENT IND RES (IN) | 2004-12-15 | — | — | EP | disclosed |
| CN-1510055-A | Composite magnesium carrier and ethene polymerization solid catalyst constituent therefrom | 中国石油化工股份有限公司 | 2004-07-07 | — | — | CN | disclosed |
| US-5962360-A | Process for the preparation of a magnesium halide supported metallocene catalyst | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 1999-10-05 | — | — | US | disclosed |
| EP-0878484-A1 | A process for the preparation of a megnesium halide supported metallocene catalyst | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 1998-11-18 | — | — | EP | disclosed |