Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL4564183 | 1.00 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL18729662 | 1.00 | — | — | |
| Tetrahydrofuran SCHEMBL1005228 | 0.95 | ALDH1A1 (0.89) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL1450115 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL22129675 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL732690 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL6345343 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL267714 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL4444183 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL4076453 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116020558-B | Pyrrole bridged ethylene oligomerization catalyst composition and application | 中国石油化工股份有限公司 | 2025-05-06 | — | — | CN | claimed |
| CN-119869609-A | Superparamagnetism supported ethylene oligomerization catalyst and preparation and fluidized bed reaction system | 中国科学院过程工程研究所 | 2025-04-25 | — | — | CN | claimed |
| CN-119552194-A | Bridged compounds, catalyst compositions and uses thereof | 中国石油化工股份有限公司 | 2025-03-04 | — | — | CN | claimed |
| CN-119552190-A | Alkenyl biphosphine bridged catalyst ligands, catalyst compositions and uses thereof | 中国石油化工股份有限公司 | 2025-03-04 | — | — | CN | claimed |
| CN-119552195-A | Biphenyl biphosphine type catalyst ligand, catalyst composition and application thereof | 中国石油化工股份有限公司 | 2025-03-04 | — | — | CN | claimed |
| CN-115991721-B | Phosphine-containing compound, preparation method thereof and application of phosphine-containing compound as ligand of ethylene oligomerization catalyst composition | 中化学科学技术研究有限公司 | 2025-02-18 | — | — | CN | claimed |
| WO-2024244137-A1 | ETHYLENE SELECTIVE TETRAMER CATALYST COMPOSITION AND PREPARATION METHOD THEREFOR | 中化泉州石化有限公司 | 2024-12-05 | — | — | WO | claimed |
| EP-3907003-B1 | HALOGEN-CONTAINING COMPOUND AND USE THEREOF AS CATALYST LIGAND IN ETHYLENE OLIGOMERIZATION | CHINA PETROLEUM & CHEM CORP (CN) | 2024-09-04 | — | — | EP | claimed |
| US-11826743-B2 | Halogen-containing compound and use thereof as catalyst ligand in ethylene oligomerization | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2023-11-28 | — | — | US | claimed |
| CN-113880881-B | Synthesis of rigid organic phosphine ligand and application of rigid organic phosphine ligand in ethylene oligomerization | 中化泉州石化有限公司 | 2023-11-17 | — | — | CN | claimed |
| CN-116713038-A | Ethylene selective tetramerization catalyst composition and preparation method thereof | 中化泉州石化有限公司 | 2023-09-08 | — | — | CN | claimed |
| CN-113354683-B | Biphosphine ligand, preparation method and application thereof | 万华化学集团股份有限公司 | 2023-05-30 | — | — | CN | claimed |
| CN-116020558-A | Pyrrole bridged ethylene oligomerization catalyst composition and application | 中国石油化工股份有限公司 | 2023-04-28 | — | — | CN | claimed |
| CN-115724883-A | Fluorine-containing ligand, fluorine-containing metal complex and ethylene oligomerization catalyst composition | 中国石油化工股份有限公司 | 2023-03-03 | — | — | CN | claimed |
| US-20220072523-A1 | HALOGEN-CONTAINING COMPOUND AND USE THEREOF AS CATALYST LIGAND IN ETHYLENE OLIGOMERIZATION | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2022-03-10 | — | — | US | claimed |
| CN-111715296-B | Ethylene tetramerization catalytic system, preparation method and application thereof | 万华化学集团股份有限公司 | 2022-02-18 | — | — | CN | claimed |
| EP-3907003-A1 | HALOGEN-CONTAINING COMPOUND AND USE THEREOF AS CATALYST LIGAND IN ETHYLENE OLIGOMERIZATION | China Petroleum & Chemical Corporation (CN) | 2021-11-10 | — | — | EP | claimed |
| CN-113354683-A | Diphosphine ligand, preparation method and application thereof | 万华化学集团股份有限公司 | 2021-09-07 | — | — | CN | claimed |
| WO-2020147372-A1 | HALOGEN-CONTAINING COMPOUND AND USE THEREOF AS CATALYST LIGAND IN ETHYLENE OLIGOMERIZATION | 中国石油化工股份有限公司 | 2020-07-23 | — | — | WO | claimed |
| WO-2020147373-A1 | HALOGEN-CONTAINING COMPOUND AND USE THEREOF, CATALYST COMPOSITION, AND ETHYLENE OLIGOMERIZATION, TRIMERIZATION AND TETRAMERIZATION METHODS | 中国石油化工股份有限公司 | 2020-07-23 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220072523-A1 | HALOGEN-CONTAINING COMPOUND AND USE THEREOF AS CATALYST LIGAND IN ETHYLENE OLIGOMERIZATION | C9, NOD1, ETV6 | ALDH1A1 3607/4885TTR 209/4885TSHR 605/4885 |
| US-11826743-B2 | Halogen-containing compound and use thereof as catalyst ligand in ethylene oligomerization | NOD1, C9, NOD2 | ALDH1A1 3578/4885TTR 241/4885TSHR 613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.