Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL1005228 | 0.95 | ALDH1A1 (0.89) | — | |
| Tetrahydrofuran SCHEMBL6361564 | 0.90 | ALDH1A1 (0.80) | — | |
| Tetrahydrofuran SCHEMBL6345343 | 0.90 | ALDH1A1 (0.80) | — | |
| Tetrahydrofuran SCHEMBL267714 | 0.90 | ALDH1A1 (0.80) | — | |
| Tetrahydrofuran SCHEMBL4444183 | 0.90 | ALDH1A1 (0.80) | — | |
| Tetrahydrofuran SCHEMBL18729662 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL1361999 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL22230565 | 0.90 | ALDH1A1 (0.80) | — | |
| Tetrahydrofuran SCHEMBL22129675 | 0.90 | ALDH1A1 (0.80) | — | |
| Tetrahydrofuran SCHEMBL4076453 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112159431-B | Preparation method of tertiary butyl arsenic | 广东先导微电子科技有限公司 | 2023-12-26 | — | — | CN | claimed |
| CN-116751223-B | Preparation method of borane tetrahydrofuran complex | 山东国邦药业有限公司 | 2023-12-08 | — | — | CN | claimed |
| CN-116751223-A | Preparation method of borane tetrahydrofuran complex | 山东国邦药业有限公司 | 2023-09-15 | — | — | CN | claimed |
| CN-113801164-A | Preparation method of trimethyl bismuth | 广东先导微电子科技有限公司 | 2021-12-17 | — | — | CN | claimed |
| CN-112159431-A | Preparation method of tert-butyl arsenic | 清远先导材料有限公司 | 2021-01-01 | — | — | CN | claimed |
| CN-106832221-B | The photocuring of structure containing oxazolidone heat reactive resin, its preparation method and the photosensitive solder resist material containing it | 佛山市三求光固材料股份有限公司 | 2017-12-29 | — | — | CN | claimed |
| CN-106966364-A | A kind of synthesis technique of deuterate aluminium lithium | 车荣睿 | 2017-07-21 | — | — | CN | claimed |
| EP-1594835-A4 | METHOD OF PREPARATION OF HETEROCYCLIC MOLECULES WITH PHARMACEUTICAL PHARMACEUTICAL EXCIPIENT COSMECEUTICAL AGROCHEMICAL AND INDUSTRIAL USES | AUSPEX PHARMACEUTICALS INC (US) | 2007-05-02 | — | — | EP | claimed |
| EP-1594835-A2 | METHOD OF PREPARATION OF HETEROCYCLIC MOLECULES WITH PHARMACEUTICAL PHARMACEUTICAL EXCIPIENT COSMECEUTICAL AGROCHEMICAL AND INDUSTRIAL USES | Auspex Pharmaceuticals, Inc. (US) | 2005-11-16 | — | — | EP | claimed |
| WO-2004064745-A2 | METHOD OF PREPARATION OF HETEROCYCLIC MOLECULES WITH PHARMACEUTICAL PHARMACEUTICAL EXCIPIENT COSMECEUTICAL AGROCHEMICAL AND INDUSTRIAL USES | AUSPEX PHARMACEUTICALS, INC. (US) | 2004-08-05 | — | — | WO | claimed |
| CN-112159431-B | Preparation method of tertiary butyl arsenic | 广东先导微电子科技有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-116751223-B | Preparation method of borane tetrahydrofuran complex | 山东国邦药业有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-116751223-B | Preparation method of borane tetrahydrofuran complex | 山东国邦药业有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-116813662-A | Synthesis process of titanium trichloride tetrahydrofuran compound (1:3) | 研峰科技(北京)有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-116751223-A | Preparation method of borane tetrahydrofuran complex | 山东国邦药业有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-1022098-C | Method for synthesizing sodium aluminum hydride | UNIV NANKAI (CN) | 1993-09-15 | — | — | CN | disclosed |
| CN-1022098-C | Method for synthesizing sodium aluminum hydride | UNIV NANKAI (CN) | 1993-09-15 | — | — | CN | disclosed |
| CN-1051179-A | The synthetic method of aluminium magnesium hydride tetrahydrofuran compound | UNIV NANKAI (CN) | 1991-05-08 | — | — | CN | disclosed |
| CN-1051152-A | The synthetic method of sodium aluminum hydride | UNIV NANKAI (CN) | 1991-05-08 | — | — | CN | disclosed |
| CN-1051152-A | The synthetic method of sodium aluminum hydride | UNIV NANKAI (CN) | 1991-05-08 | — | — | CN | disclosed |