Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | DRD2 | P14416 | 7/20 | 0.66 |
| ▸ | DRD4 | P21917 | 6/20 | 0.66 |
| ▸ | DRD3 | P35462 | 4/20 | 0.66 |
| ▸ | HTR1A | P08908 | 7/20 | 0.60 |
| ▸ | HTR1D | P28221 | 7/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 2/20 | 0.56 |
| ▸ | HTR1B | P28222 | 4/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6907354 | 0.83 | DRD4 (0.66) | DRD2DRD4DRD3HTR1AHTR1D | |
| SCHEMBL29384882 | 0.80 | KMT2A (1.00) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL677470 | 0.80 | KMT2A (1.00) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6906039 | 0.80 | DRD4 (1.00) | DRD2DRD4DRD3HTR1AHTR1D | |
| SCHEMBL6906613 | 0.79 | DRD2 (0.64) | DRD2DRD4DRD3HTR1AHTR1D | |
| SCHEMBL6910011 | 0.77 | DRD4 (0.78) | DRD2DRD4DRD3HTR1AHTR1D | |
| SCHEMBL6909127 | 0.77 | DRD2 (0.74) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7756335 | 0.76 | RAB9A (0.74) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4177932 | 0.75 | HTR1D (1.00) | DRD2DRD4DRD3HTR1AHTR1D | |
| SCHEMBL6906093 | 0.75 | DRD2 (0.70) | CYP3A4CYP2D6CYP2C9DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906294-B1 | BENZOXAZINONE DOPAMINE D4 RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2003-01-29 | — | — | EP | claimed |
| US-20020052373-A1 | Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease | ZORN STEVIN H (US) | 2002-05-02 | — | — | US | claimed |
| EP-1201268-A2 | Combinations of D4 dopamine receptor antagonists with acetylcholine esterase inhibitors | Pfizer Products Inc. (US) | 2002-05-02 | — | — | EP | claimed |
| US-6177422-B1 | ANTIPSYCHOTIC AGENT WITH REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | claimed |
| US-20040048869-A1 | Combination treatment for depression, anxiety and psychosis | PFIZER INC | 2004-03-11 | — | — | US | disclosed |
| EP-0906294-B1 | BENZOXAZINONE DOPAMINE D4 RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2003-01-29 | — | — | EP | disclosed |
| US-20020094986-A1 | Combination treatment for depression, anxiety and psychosis | PFIZER INC | 2002-07-18 | — | — | US | disclosed |
| EP-1213031-A2 | Combination treatment for depression, anxiety and psychosis comprising an antidepressant and/or anxiolytic and a D4 receptor antagonist | Pfizer Products Inc. (US) | 2002-06-12 | — | — | EP | disclosed |
| US-20020052373-A1 | Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease | ZORN STEVIN H (US) | 2002-05-02 | — | — | US | disclosed |
| EP-1201268-A2 | Combinations of D4 dopamine receptor antagonists with acetylcholine esterase inhibitors | Pfizer Products Inc. (US) | 2002-05-02 | — | — | EP | disclosed |
| US-6177422-B1 | ANTIPSYCHOTIC AGENT WITH REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020094986-A1 | Combination treatment for depression, anxiety and psychosis | HTR4, CHRNA4, GRM4 | MEN1 3624/4885KMT2A 2972/4885CYP1A2 1259/4885 |
| US-20020052373-A1 | Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease | ACHE, BCHE, CHRM4 | MEN1 3739/4885KMT2A 2509/4885CYP1A2 1414/4885 |
| US-20040048869-A1 | Combination treatment for depression, anxiety and psychosis | HTR4, CHRNA4, GRM4 | MEN1 3624/4885KMT2A 2972/4885CYP1A2 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.