Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6797367 | 0.86 | HTR2A (0.43) | HTR1AHTR2AHTR2CDRD2HTR2B | |
| SCHEMBL6906280 | 0.76 | HTR1A (0.61) | HTR1AHTR2AHTR2CDRD2HTR2B | |
| SCHEMBL7247392 | 0.73 | HTR1A (0.42) | HTR1A | |
| SCHEMBL6782174 | 0.73 | HTR2A (0.51) | HTR1AHTR2AHTR2CDRD2HTR2B | |
| SCHEMBL6630732 | 0.71 | HTR1A (0.46) | HTR1ADRD2LMNAGAA | |
| SCHEMBL6109572 | 0.71 | HTR1A (0.46) | HTR1ADRD2LMNAGAA | |
| SCHEMBL4335129 | 0.71 | NR3C1 (0.37) | HTR1AALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL7236260 | 0.70 | CA2 (0.35) | HTR1A | |
| SCHEMBL7240006 | 0.70 | CA2 (0.35) | HTR1A | |
| SCHEMBL6630585 | 0.70 | HTR1A (0.39) | HTR1ADRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800642-B2 | SUCH AS BENZYL-(-7,8-DIHYDRO-2,6,9-TRIOXA-3-AZA-CYCLOPENTA(A)NAPHTHALEN-8-YLMETHYL) -AMINE; FOR TREATMENT OF DRUG DEPENDENCE/ADDICTION, BIPOLAR DISORDER, PARKINSON'S DISEASE, LEVODOPA INDUCED PSYCHOSES OR DYSKINESIAS | WYETH | 2004-10-05 | — | — | US | disclosed |