Benzamide

Benzamide

SCHEMBL6906372

CC1=C(C)C(C)C([Zr+2](C)C)=C1C.NC(=O)c1ccccc1.[Cl-].[Cl-].[SiH4]

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Benzamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.32
PARP1 P09874 4/20 0.46
POLB P06746 1/20 0.46
CYP3A4 P08684 1/20 0.46
MAPT P10636 1/20 0.46
TSHR P16473 1/20 0.46
CYP2C19 P33261 1/20 0.46
RECQL P46063 1/20 0.46
BLM P54132 1/20 0.46
PMP22 Q01453 1/20 0.46
HSD17B10 Q99714 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
PLA2G10 O15496 1/20 0.38
PLA2G2A P14555 1/20 0.38
F7 P08709 1/20 0.36
F3 P13726 1/20 0.36
SARM1 Q6SZW1 1/20 0.36
SIRT2 Q8IXJ6 1/20 0.36
SIRT6 Q8N6T7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzamide SCHEMBL3354505 0.77 PARP1 (0.46) PARP1POLBCYP3A4MAPTTSHR
Hydrochloric Acid SCHEMBL8858052 0.72 CES2 (0.31) CES2CES1
Benzamide SCHEMBL5616740 0.70 PARP1 (0.94) PARP1POLBCYP3A4MAPTTSHR
Benzamide SCHEMBL5616741 0.70 PARP1 (0.94) PARP1POLBCYP3A4MAPTTSHR
Benzoic Acid SCHEMBL8094668 0.68 CA2 (0.57) TSHRCES2CES1ALDH1A1
Benzamide SCHEMBL2061911 0.68 PARP1 (0.89) PARP1POLBCYP3A4MAPTTSHR
Benzamide SCHEMBL28132124 0.68 PARP1 (0.89) PARP1POLBCYP3A4MAPTTSHR
Benzamide SCHEMBL27340650 0.68 PARP1 (0.89) PARP1POLBCYP3A4MAPTTSHR
Benzamide SCHEMBL8632915 0.68 PARP1 (0.89) PARP1POLBCYP3A4MAPTTSHR
Benzamide SCHEMBL3870712 0.68 PARP1 (0.89) PARP1POLBCYP3A4MAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0839842-B1 Film made from an Ethylene-alpha-olefin copolymer MITSUBISHI CHEM CORP (JP) 2004-04-14 EP disclosed
US-6448356-B1 NARROW MOLECULAR WEIGHT DISTRIBUTION; CONTROLLING DENSITY MITSUBISHI CHEMICAL CORPORATION (JP) 2002-09-10 US disclosed
US-20020035227-A1 Ethylene-alpha-olefin copolymer MITSUBISHI CHEMICAL CORPORATION (JP) 2002-03-21 US disclosed
EP-0683180-B1 Catalyst for polymerizing an olefin and method for polymerizing the olefin MITSUBISHI CHEM CORP (JP) 2002-03-06 EP disclosed
US-5973084-A HOMO OR COPOLYMERIZING AN ALPHA-OLEFIN IN PRESENCE OF A CATALYTIC SYSTEM CONTAINING METALLOCENE TYPE TRANSITIONAL METAL COMPOUND, AN ION EXCHANGED LAYERED COMPOUND OTHER THAN SILICATE AND AN INORGANIC ACID OR SALT TREATED SILICATE MITSUBISHI CHEMICAL CORPORATION (JP) 1999-10-26 US disclosed
US-5928982-A METALLOCENE TRANSITION METAL COMPOUND, (1) AN ION-EXCHANGING LAYERED COMPOUND OTHER THAN A SILICATE OR (2) AN INORGANIC SILICATE PREPARED BY TREATING A STARTING ION-EXCHANGING LAYER COMPOUND OTHER THAN A SILICATE OR A STARTING SILICATE WITH A MITSUBISHI CHEMICAL CORPORATION (JP) 1999-07-27 US disclosed
EP-0839842-A2 Ethylene-alpha-olefin copolymer MITSUBISHI CHEMICAL CORPORATION (JP) 1998-05-06 EP disclosed
EP-0683180-A2 Catalyst for polymerizing an olefin and method for polymerizing the olefin MITSUBISHI CHEMICAL CORPORATION (JP) 1995-11-22 EP disclosed