Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.97 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.97 |
| ▸ | MPO | P05164 | 5/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.68 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.62 |
| ▸ | HTR1D | P28221 | 2/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethane SCHEMBL26617453 | 0.98 | HTR2A (0.97) | HTR2AMAPTSMN1; SMN2NPSR1MPO | |
| Iodide SCHEMBL27094895 | 0.98 | HTR2A (0.97) | HTR2AMAPTSMN1; SMN2NPSR1MPO | |
| Hydrochloric Acid SCHEMBL31109030 | 0.98 | MAPT (1.00) | HTR2AMAPTSMN1; SMN2NPSR1MPO | |
| Hydrochloric Acid SCHEMBL7818408 | 0.98 | MAPT (1.00) | HTR2AMAPTSMN1; SMN2NPSR1MPO | |
| Cyanide SCHEMBL28688618 | 0.95 | HTR2A (0.91) | HTR2AMAPTSMN1; SMN2NPSR1MPO | |
| SCHEMBL8055335 | 0.84 | HTR2A (0.73) | HTR2AMAPTSMN1; SMN2NPSR1MPO | |
| SCHEMBL4803628 | 0.83 | HTR2A (0.71) | HTR2AMAPTSMN1; SMN2NPSR1MPO | |
| SCHEMBL27911678 | 0.82 | HTR2A (0.69) | HTR2AMAPTSMN1; SMN2NPSR1MPO | |
| SCHEMBL13715289 | 0.81 | HTR2A (0.69) | HTR2AMAPTSMN1; SMN2NPSR1MPO | |
| SCHEMBL1968447 | 0.81 | MPO (1.00) | HTR2AMAPTSMN1; SMN2NPSR1MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112500412-A | Penamine A alkaloid structure simplification compound and application thereof | 中国人民解放军空军军医大学 | 2021-03-16 | — | — | CN | claimed |
| EP-1869053-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-10-09 | — | — | EP | claimed |
| US-7829568-B2 | Substituted 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylamine compounds and their use for producing drugs | GRUENENTHAL GMBH (DE) | 2010-11-09 | — | — | US | claimed |
| EP-1869038-B1 | SUBSTITUTED 5,6,7,8-TETRAHYDRO-IMIDAZO[1,2-A]PYRIDIN-2-YLAMINE COMPOUNDS AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-07-08 | — | — | EP | claimed |
| US-20090076001-A1 | Substituted 4,5,6,7 -Tetrahydro-Isoxazolo[4,5-C]Pyridine Compounds and Use Thereof for Producing Medicaments | GRUENENTHAL GMBH (DE) | 2009-03-19 | — | — | US | claimed |
| US-20080300256-A1 | Substituted 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-2-ylamine Compounds and Their Use for Producing Drugs | GRUENENTHAL GMBH (DE) | 2008-12-04 | — | — | US | claimed |
| EP-1685150-B1 | NOVEL 17beta HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | SOLVAY PHARM GMBH (DE) | 2008-09-03 | — | — | EP | claimed |
| US-3930948-A | ENZYMATIC METHOD FOR PRODUCING AROMATIC ETHYLAMINES | AJINOMOTO CO., INC. (JA) | 1976-01-06 | — | — | US | claimed |
| WO-2024040158-A3 | TRYPTAMINE DERIVATIVES | CAAMTECH, INC. (US) | 2024-03-28 | — | — | WO | disclosed |
| WO-2024040158-A2 | TRYPTAMINE DERIVATIVES | CAAMTECH, INC. (US) | 2024-02-22 | — | — | WO | disclosed |
| CN-115850269-A | Tetrahydro-beta-carboline compound and preparation method and application thereof | 南京工业大学 | 2023-03-28 | — | — | CN | disclosed |
| CN-115785091-A | Method for catalytically synthesizing tetrahydro-beta-carboline compound by utilizing PNP type pincerlike manganese catalyst | 邵秀兰 | 2023-03-14 | — | — | CN | disclosed |
| US-11583524-B2 | Inhibitors of the interaction between MDM2 and P53 | JANSSEN PHARMACEUTICA NV (BE) | 2023-02-21 | — | — | US | disclosed |
| WO-2023278403-A2 | CRYSTALLINE HYDROCHLORIDE SALTS OF SUBSTITUTED TRYPTAMINES | CAAMTECH, INC. (US) | 2023-01-05 | — | — | WO | disclosed |
| EP-1392641-A1 | SUBSTITUTED CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2004-03-03 | — | — | EP | disclosed |
| EP-1385493-A1 | SUBSTITUTED CYCLOHEXAN-1,4-DIAMINE DERIVATIVES WITH CONSTIPATING AND PERIPHERAL ANALGESIC PROPERTIES | Grünenthal GmbH (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002090317-A1 | SUBSTITUTED CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-14 | — | — | WO | disclosed |
| WO-2002089783-A1 | SUBSTITUTED CYCLOHEXAN-1,4-DIAMINE DERIVATIVES WITH CONSTIPATING AND PERIPHERAL ANALGESIC PROPERTIES | Grünenthal GmbH (DE) | 2002-11-14 | — | — | WO | disclosed |
| US-4978669-A | ALTERING MACRONUTRIENT PREFERENCE | NEUREX CORPORATION (US) | 1990-12-18 | — | — | US | disclosed |
| US-4565870-A | Process for the preparation of a salt of 1-(γ-halopropyl)-1,2,3,4-β-carbolines | BASF AKTIENGESELLSCHAFT (DE) | 1986-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076001-A1 | Substituted 4,5,6,7 -Tetrahydro-Isoxazolo[4,5-C]Pyridine Compounds and Use Thereof for Producing Medicaments | P2RX5, P2RX4, P2RX7 | HTR2A 798/4885MAPT 3693/4885SMN1; SMN2 4525/4885 |
| US-20080300256-A1 | Substituted 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-2-ylamine Compounds and Their Use for Producing Drugs | CYP3A7, CYP3A5, CYP2D6 | HTR2A 43/4885MAPT 1460/4885SMN1; SMN2 1159/4885 |
| US-11583524-B2 | Inhibitors of the interaction between MDM2 and P53 | TP53, MDM2, TP53BP1 | HTR2A 3374/4885MAPT 1187/4885SMN1; SMN2 3777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.