Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 15/20 | 0.69 |
| ▸ | CA2 | P00918 | 15/20 | 0.69 |
| ▸ | CA9 | Q16790 | 14/20 | 0.66 |
| ▸ | CA12 | O43570 | 9/20 | 0.66 |
| ▸ | CA4 | P22748 | 5/20 | 0.66 |
| ▸ | CA6 | P23280 | 5/20 | 0.66 |
| ▸ | CA5A | P35218 | 5/20 | 0.66 |
| ▸ | CA7 | P43166 | 5/20 | 0.66 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.66 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.66 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.66 |
| ▸ | APEX1 | P27695 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5564627 | 0.87 | CA1 (0.64) | CA1CA2CA9CA12CA4 | |
| SCHEMBL31070438 | 0.82 | CA1 (1.00) | CA1CA2CA9CA12F2 | |
| SCHEMBL9463563 | 0.82 | CA1 (0.63) | CA1CA2CA9CA12CA4 | |
| SCHEMBL1804698 | 0.82 | CA1 (1.00) | CA1CA2CA9CA12F2 | |
| Dichlorphenamide SCHEMBL112376 | 0.79 | CA1 (1.00) | CA1CA2CA9CA12CA4 | |
| Dichlorphenamide SCHEMBL29355725 | 0.79 | CA1 (1.00) | CA1CA2CA9CA12CA4 | |
| SCHEMBL9518035 | 0.79 | APEX1 (1.00) | CA1CA2CA9CA12CA4 | |
| SCHEMBL22022107 | 0.78 | CA1 (0.67) | CA1CA2 | |
| SCHEMBL29780561 | 0.78 | CA2 (0.65) | CA1CA2CA9CA12CA4 | |
| Dichlorphenamide SCHEMBL4312398 | 0.78 | CA1 (0.96) | CA1CA2CA9CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040186155-A1 | Combination therapy for the treatment or prevention of migraine | DAYNO JEFFREY MARC (US) | 2004-09-23 | — | — | US | disclosed |
| EP-0276057-B1 | Piperazinylpyrimidines as beta-adrenergic receptor blocking agents | MERCK & CO INC (US) | 1994-03-09 | — | — | EP | disclosed |
| US-5157044-A | Treating glaucoma | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1992-10-20 | — | — | US | disclosed |
| US-5095026-A | PRODRUGS OF CARBONIC ANHYDRASE INHIBITORS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1992-03-10 | — | — | US | disclosed |
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4994464-A | Treatment of elevated intraocular pressure and glaucoma | MERCK & CO., INC. (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0122831-B1 | BENZOTHIAZOLE-2-SULFONAMIDE DERIVATIVES FOR THE TOPICAL TREATMENT OF ELEVATED INTRAOCULAR PRESSURE | MERCK & CO. INC. (US) | 1990-04-18 | — | — | EP | disclosed |
| US-4889856-A | INTRAOCULAR PRESSURE REDUCTION; CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1989-12-26 | — | — | US | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |
| EP-0276057-A2 | Piperazinylpyrimidines as beta-adrenergic receptor blocking agents | MERCK & CO. INC. (US) | 1988-07-27 | — | — | EP | disclosed |
| US-4499103-A | Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure | MERCK & CO., INC. (US) | 1985-02-12 | — | — | US | disclosed |
| EP-0122831-A2 | Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1984-10-24 | — | — | EP | disclosed |
| US-4045558-A | Pilocarpine salts | MERCK & CO., INC. (US) | 1977-08-30 | — | — | US | disclosed |
| US-4045558-A | Pilocarpine salts | MERCK & CO., INC. (US) | 1977-08-30 | — | — | US | disclosed |