Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TYMS | P04818 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | TLR4 | O00206 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12717617 | 0.95 | DHFR (0.65) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| SCHEMBL864864 | 0.92 | DHFR (0.79) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| SCHEMBL1021371 | 0.92 | DHFR (0.79) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Folic Acid SCHEMBL29677832 | 0.91 | KDM4E (0.73) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Folic Acid SCHEMBL3878 | 0.91 | KDM4E (0.73) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Folic Acid SCHEMBL6470174 | 0.91 | KDM4E (0.73) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Folic Acid SCHEMBL12148554 | 0.91 | KDM4E (0.73) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Folic Acid SCHEMBL23388805 | 0.90 | KDM4E (0.72) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Folic Acid SCHEMBL22441084 | 0.90 | KDM4E (0.72) | DHFRKDM4EMEN1ALDH1A1TYMS | |
| Folic Acid SCHEMBL652283 | 0.90 | KDM4E (0.72) | DHFRKDM4EMEN1ALDH1A1TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689756-B2 | VIA CATHETER COMPRISING ANTIMICROBIAL AGENT AND SECOND CATHETER FOR WITHDRAWING FLUID; FOR TREATING INFECTION OR NEOPLASM OF CEREBROSPINAL TISSUE | INTEGRA LIFESCIENCES CORPORATION | 2004-02-10 | — | — | US | disclosed |
| US-20030022879-A1 | Treatment of neurological disease | INTEGRA LIFESCIENCES CORPORATION | 2003-01-30 | — | — | US | disclosed |
| WO-2002069893-A2 | TREATMENT OF NEUROLOGICAL DISEASE | NEURON THERAPEUTICS, INC. (US) | 2002-09-12 | — | — | WO | disclosed |