Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | TYMS | P04818 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.73 |
| ▸ | DHFR | P00374 | 9/20 | 0.67 |
| ▸ | TLR4 | O00206 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Folic Acid SCHEMBL6470174 | 1.00 | KDM4E (0.73) | KDM4EMEN1ALDH1A1TYMSPOLB | |
| Folic Acid SCHEMBL3878 | 1.00 | KDM4E (0.73) | KDM4EMEN1ALDH1A1TYMSPOLB | |
| Folic Acid SCHEMBL29677832 | 1.00 | KDM4E (0.73) | KDM4EMEN1ALDH1A1TYMSPOLB | |
| Folic Acid SCHEMBL1887022 | 0.99 | KDM4E (0.72) | KDM4EMEN1ALDH1A1TYMSPOLB | |
| Folic Acid SCHEMBL12497751 | 0.99 | KDM4E (0.72) | KDM4EMEN1ALDH1A1TYMSPOLB | |
| Folic Acid SCHEMBL23388805 | 0.99 | KDM4E (0.72) | KDM4EMEN1ALDH1A1TYMSPOLB | |
| Folic Acid SCHEMBL19837676 | 0.99 | KDM4E (0.72) | KDM4EMEN1ALDH1A1TYMSPOLB | |
| Folic Acid SCHEMBL652283 | 0.99 | KDM4E (0.72) | KDM4EMEN1ALDH1A1TYMSPOLB | |
| Folic Acid SCHEMBL22441084 | 0.99 | KDM4E (0.72) | KDM4EMEN1ALDH1A1TYMSPOLB | |
| Folic Acid SCHEMBL842691 | 0.99 | KDM4E (0.72) | KDM4EMEN1ALDH1A1TYMSPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160143927-A1 | Compounds, Methods, and Treatments for Abnormal Signaling Pathways for Prenatal and Postnatal Development | JENNINGS BARBARA BROOKE (US) | 2016-05-26 | — | — | US | disclosed |
| US-20160143927-A1 | Compounds, Methods, and Treatments for Abnormal Signaling Pathways for Prenatal and Postnatal Development | JENNINGS BARBARA BROOKE (US) | 2016-05-26 | — | — | US | disclosed |
| US-8426398-B2 | Conjugates of noscapine and folic acid and their use in treating cancer | EMORY UNIVERSITY (US) | 2013-04-23 | — | — | US | disclosed |
| US-8426398-B2 | Conjugates of noscapine and folic acid and their use in treating cancer | EMORY UNIVERSITY (US) | 2013-04-23 | — | — | US | disclosed |
| US-20110286919-A1 | CONJUGATES OF NOSCAPINE AND FOLIC ACID AND THEIR USE IN TREATING CANCER | EMORY UNIVERSITY (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110286919-A1 | CONJUGATES OF NOSCAPINE AND FOLIC ACID AND THEIR USE IN TREATING CANCER | EMORY UNIVERSITY (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110218176-A1 | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development | JENNINGS-SPRING BARBARA BROOKE | 2011-09-08 | — | — | US | disclosed |
| US-20110218176-A1 | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development | JENNINGS-SPRING BARBARA BROOKE | 2011-09-08 | — | — | US | disclosed |
| US-20090214474-A1 | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development | JENNINGS BARBARA BROOKE | 2009-08-27 | — | — | US | disclosed |
| US-20090214474-A1 | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development | JENNINGS BARBARA BROOKE | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160143927-A1 | Compounds, Methods, and Treatments for Abnormal Signaling Pathways for Prenatal and Postnatal Development | PDK1, PKM, PDK2 | KDM4E 824/4885MEN1 4142/4885ALDH1A1 1758/4885 |
| US-20110218176-A1 | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development | PDK1, PKM, PDK2 | KDM4E 824/4885MEN1 4142/4885ALDH1A1 1758/4885 |
| US-20110286919-A1 | CONJUGATES OF NOSCAPINE AND FOLIC ACID AND THEIR USE IN TREATING CANCER | FOLR1, FOLR2, DHFR | KDM4E 4392/4885MEN1 1207/4885ALDH1A1 1787/4885 |
| US-20090214474-A1 | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development | SHH, ERH, CDK5 | KDM4E 3060/4885MEN1 3949/4885ALDH1A1 1846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.