Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | SLC40A1 | Q9NP59 | 4/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21708271 | 0.81 | L3MBTL1 (0.66) | ALDH1A1GAAHTTHSD17B10SLC40A1 | |
| SCHEMBL14960618 | 0.80 | SLC40A1 (0.52) | ALDH1A1GAAHTTSLC40A1SLC22A12 | |
| SCHEMBL12320158 | 0.78 | PTGS1 (0.53) | ALDH1A1SLC40A1SLC22A12SMN1; SMN2L3MBTL1 | |
| SCHEMBL16235233 | 0.77 | GAA (0.56) | ALDH1A1GAAHTTHSD17B10SLC40A1 | |
| SCHEMBL12277043 | 0.77 | SLC22A12 (0.48) | ALDH1A1GAAHTTSLC40A1SLC22A12 | |
| SCHEMBL6910838 | 0.76 | LMNA (0.55) | ALDH1A1HTTSLC40A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2205091 | 0.73 | ALDH1A1 (0.52) | ALDH1A1GAAHTTHSD17B10SLC40A1 | |
| SCHEMBL10212607 | 0.73 | ALDH1A1 (0.58) | ALDH1A1GAAHTTHSD17B10SLC40A1 | |
| SCHEMBL29337 | 0.72 | BDKRB1 (0.53) | HTTKMT2APOLBMEN1MAPT | |
| SCHEMBL28450035 | 0.72 | SLC22A12 (0.74) | SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079114-A1 | PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2011-06-30 | — | — | WO | disclosed |