Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 7/20 | 0.65 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | MELK | Q14680 | 1/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.51 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.51 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6910983 | 1.00 | ADK (0.65) | ADKCDK1CDK2DOT1LDCLK1 | |
| SCHEMBL6910971 | 0.88 | ADK (0.58) | ADKCDK1CDK2DOT1LDCLK1 | |
| SCHEMBL6910965 | 0.88 | ADK (0.58) | ADKCDK1CDK2DOT1LDCLK1 | |
| SCHEMBL3490107 | 0.86 | ATG7 (0.52) | ADKCDK1CDK2DOT1LDCLK1 | |
| Hydrochloric Acid SCHEMBL31238488 | 0.82 | ADK (0.52) | ADKCDK1CDK2DOT1LDCLK1 | |
| SCHEMBL3211889 | 0.82 | ADK (0.49) | ADKCDK1CDK2DOT1LDCLK1 | |
| SCHEMBL8975866 | 0.79 | ADK (1.00) | ADKCDK1CDK2DOT1LDCLK1 | |
| SCHEMBL8975520 | 0.77 | ADK (0.75) | ADKCDK1CDK2DOT1LDCLK1 | |
| SCHEMBL6912039 | 0.77 | ALDH1A1 (0.55) | ADKDOT1LMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1144829 | 0.77 | ALDH1A1 (0.55) | ADKDOT1LMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0961775-B1 | PURINE L-NUCLEOSIDES, ANALOGS AND USES THEREOF | ICN PHARMACEUTICALS (US) | 2004-07-14 | — | — | EP | disclosed |
| US-6479463-B1 | USED TO TREAT AN INFECTION, AN INFESTATION, A NEOPLASM, OR AN AUTOIMMUNE DISEASE OR TO MODULATE ASPECTS OF THE IMMUNE SYSTEM, INCLUDING MODULATION OF TH1 AND TH2 | ICN PHARMACEUTICALS, INC. | 2002-11-12 | — | — | US | disclosed |