Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348748 | 0.90 | GAA (0.46) | GAANOX4ALDH1A1KDM4EBTK | |
| SCHEMBL2347967 | 0.87 | FAAH (0.45) | GAANOX4CHRM3KDM4E | |
| SCHEMBL6911739 | 0.87 | SLC6A5 (0.42) | GAACHRM3DDB1CRBNMEN1 | |
| SCHEMBL2344747 | 0.86 | KDM4E (0.43) | GAANOX4ALDH1A1KDM4ETSHR | |
| SCHEMBL6909746 | 0.83 | MEN1 (0.41) | GAANOX4ALDH1A1KDM4EBTK | |
| SCHEMBL6911686 | 0.81 | MEN1 (0.51) | GAANOX4MEN1KMT2ATSHR | |
| SCHEMBL6911338 | 0.80 | MEN1 (0.44) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2302100 | 0.79 | KDM4E (0.43) | GAANOX4ALDH1A1KDM4ETSHR | |
| SCHEMBL6911024 | 0.78 | BRS3 (0.44) | GAAALDH1A1KDM4ETDP1TSHR | |
| SCHEMBL2301441 | 0.78 | MAPT (0.42) | GAANOX4ALDH1A1KDM4EBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101805-A1 | PYRAZOLO PIPERIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-08-25 | — | — | WO | disclosed |