Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CLPP | Q16740 | 5/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYBB | P04839 | 2/20 | 0.41 |
| ▸ | NOX5 | Q96PH1 | 2/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6911739 | 0.93 | SLC6A5 (0.42) | MEN1GAAKMT2AATMCLPP | |
| SCHEMBL2352634 | 0.90 | MEN1 (0.54) | MEN1GAAKMT2AATMCLPP | |
| SCHEMBL6911338 | 0.89 | MEN1 (0.44) | MEN1GAAKMT2AATMCLPP | |
| SCHEMBL2343325 | 0.88 | MEN1 (0.54) | MEN1GAAKMT2AATMCLPP | |
| SCHEMBL2350571 | 0.86 | DRD2 (0.55) | MEN1GAAKMT2AATMCLPP | |
| SCHEMBL2347778 | 0.85 | CLPP (0.49) | MEN1GAAKMT2AATMCLPP | |
| SCHEMBL6911024 | 0.85 | BRS3 (0.44) | GAACLPPDRD2DRD3SLC6A5 | |
| SCHEMBL6910461 | 0.85 | MEN1 (0.37) | MEN1GAAKMT2AATMCLPP | |
| SCHEMBL6910467 | 0.84 | COMT (0.42) | CLPPDRD2CYBBNOX5NOX4 | |
| SCHEMBL6907625 | 0.84 | CLPP (0.42) | MEN1KMT2ACLPPDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101805-A1 | PYRAZOLO PIPERIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-08-25 | — | — | WO | disclosed |