Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15842979 | 0.67 | CYP2C9 (0.37) | LMNASMN1; SMN2 | |
| SCHEMBL15843105 | 0.65 | ALDH1A1 (0.33) | NOS3NOS1NOS2LMNASMN1; SMN2 | |
| SCHEMBL15842989 | 0.65 | NISCH (0.46) | ALDH1A1MAPTATM | |
| SCHEMBL2492257 | 0.65 | KDM4E (0.48) | LMNASMN1; SMN2ALDH1A1MAPTATM | |
| SCHEMBL11128734 | 0.63 | ALDH1A1 (0.42) | NOS3NOS1NOS2LMNASMN1; SMN2 | |
| SCHEMBL12463587 | 0.62 | NPC1 (0.35) | LMNASMN1; SMN2ALDH1A1MAPTATM | |
| SCHEMBL15843270 | 0.61 | NOS3 (0.34) | NOS3NOS1NOS2LMNASMN1; SMN2 | |
| SCHEMBL18806856 | 0.60 | — | — | |
| SCHEMBL14404017 | 0.60 | NPC1 (0.41) | LMNASMN1; SMN2MAPT | |
| SCHEMBL402898 | 0.59 | PDPK1 (0.39) | NOS3NOS1NOS2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079114-A1 | PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2011-06-30 | — | — | WO | disclosed |