Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL102331 | 0.69 | PDPK1 (0.59) | PDPK1LOXL2CYP2A6ADORA2AHSP90AA1 | |
| SCHEMBL11128734 | 0.68 | ALDH1A1 (0.42) | ALDH1A1NOS1MAPTATMRAB9A | |
| SCHEMBL29244163 | 0.68 | PDPK1 (0.39) | PDPK1LOXL2CYP2A6ADORA2AHSP90AA1 | |
| SCHEMBL30534095 | 0.67 | PDPK1 (0.56) | PDPK1LOXL2CYP2A6ADORA2AHSP90AA1 | |
| SCHEMBL30632310 | 0.67 | PDPK1 (0.56) | PDPK1LOXL2CYP2A6ADORA2AHSP90AA1 | |
| SCHEMBL31556353 | 0.67 | PDPK1 (0.56) | PDPK1LOXL2CYP2A6ADORA2AHSP90AA1 | |
| SCHEMBL28154527 | 0.67 | PDPK1 (0.56) | PDPK1LOXL2CYP2A6ADORA2AHSP90AA1 | |
| Aminothiazole SCHEMBL27579629 | 0.67 | NOS2 (0.61) | HSP90AA1ALDH1A1NOS1TSHRHSD17B10 | |
| SCHEMBL27691005 | 0.66 | ALDH1A1 (0.46) | ADORA2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL21689149 | 0.65 | NOS3 (0.39) | NOS1NOS3NOS2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107151243-B | 2-substituted-4-methyl-5- (4, 5-dihydrothiazole-2-yl) -1, 3-thiazole compounds, preparation method and biological activity evaluation thereof | 江苏海洋大学 | 2020-09-08 | — | — | CN | claimed |
| CN-107151243-A | 24 methyl 5 of substitution（The base of 4,5 thiazoline 2）1,3 thiazole compounds and preparation method thereof and biological evaluation | 淮海工学院 | 2017-09-12 | — | — | CN | claimed |
| CN-104892543-B | Thiazole compounds, as well as synthesis method and application thereof | 南京林业大学 | 2017-02-22 | — | — | CN | claimed |
| EP-2378877-A1 | IMIDAZOLINONE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2011-10-26 | — | — | EP | claimed |
| WO-2010077752-A1 | IMIDAZOLINONE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-07-08 | — | — | WO | claimed |
| CN-110755425-B | Application of Largazole in preparation of medicine for treating diseases caused by overexpression of Msi1 gene ectopy | 中国农业大学 | 2022-06-24 | — | — | CN | disclosed |
| US-11319347-B2 | Peptide compound and method for producing same, composition for screening use, and method for selecting peptide compound | FUJIFILM CORPORATION (JP) | 2022-05-03 | — | — | US | disclosed |
| US-20220024912-A1 | COMPOUNDS FOR TREATMENT OF CANCER | Oncternal Therapeutics, Inc. (US) | 2022-01-27 | — | — | US | disclosed |
| US-11084811-B2 | Compounds for treatment of cancer | Oncternal Therapeutics, Inc. (US) | 2021-08-10 | — | — | US | disclosed |
| CN-110172067-B | Thiazole medicine molecule with bactericidal activity and preparation method thereof | 河南科技大学第一附属医院 | 2021-06-15 | — | — | CN | disclosed |
| CN-107151243-B | 2-substituted-4-methyl-5- (4, 5-dihydrothiazole-2-yl) -1, 3-thiazole compounds, preparation method and biological activity evaluation thereof | 江苏海洋大学 | 2020-09-08 | — | — | CN | disclosed |
| US-10676504-B2 | Method for preparing largazole analogs and uses thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2020-06-09 | — | — | US | disclosed |
| WO-2003080828-A2 | NUCLEIC ACID MOLECULES INVOLVED IN THE SYNTHESIS OF MELITHIAZOLS | GBF - GESELLSCHAFT FÜR BIOTECHNOLOGISCHEFORSCHUNG M.B.H. (DE) | 2003-10-02 | — | — | WO | disclosed |
| US-5518874-A | FORMING GRAINS IN THE PRESENCE OF SPECIFIED COMPOUND | KONICA CORPORATION (JP) | 1996-05-21 | — | — | US | disclosed |
| EP-0462579-A1 | Method of manufacturing a silver halide emulsion | KONICA CORPORATION (JP) | 1991-12-27 | — | — | EP | disclosed |
| EP-0365348-A2 | A silver halide color photographic light-sensitive material | KONICA CORPORATION (JP) | 1990-04-25 | — | — | EP | disclosed |
| US-4576938-A | Cephalosporin compound and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1986-03-18 | — | — | US | disclosed |
| EP-0014476-B1 | OPTICALLY ACTIVE ACYLATED CEPHALOSPORIN ANALOGS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1983-08-10 | — | — | EP | disclosed |
| EP-0081971-A2 | Novel cephalosporin compound and process for preparing the same | Tanabe Seiyaku Co., Ltd. (JP) | 1983-06-22 | — | — | EP | disclosed |
| US-4188382-A | Thiazolinyl (thiazolyl) phosphonamidates and phosphoramidates pesticidal and herbicidal compositions based thereon | Vsesojuzny Nauchno, et al. (SU) | 1980-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10676504-B2 | Method for preparing largazole analogs and uses thereof | CYP51A1, ADPRS, LPXN | PDPK1 3320/4885LOXL2 1161/4885CYP2A6 315/4885 |
| US-11084811-B2 | Compounds for treatment of cancer | KLK3, BRDT, ACP3 | PDPK1 278/4885LOXL2 2211/4885CYP2A6 4046/4885 |
| US-20220024912-A1 | COMPOUNDS FOR TREATMENT OF CANCER | KLK3, BRDT, ACP3 | PDPK1 278/4885LOXL2 2211/4885CYP2A6 4046/4885 |
| US-11319347-B2 | Peptide compound and method for producing same, composition for screening use, and method for selecting peptide compound | VIP, NPPA, NGLY1 | PDPK1 2536/4885LOXL2 4195/4885CYP2A6 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.