Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GSR | P00390 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nimustine SCHEMBL23301409 | 0.82 | BLM (1.00) | BLMPMP22LMNANFKB1MEN1 | |
| Nimustine SCHEMBL8414 | 0.82 | BLM (1.00) | BLMPMP22LMNANFKB1MEN1 | |
| Nimustine SCHEMBL98303 | 0.81 | BLM (0.98) | BLMPMP22LMNANFKB1MEN1 | |
| Nimustine SCHEMBL1649545 | 0.81 | BLM (0.98) | BLMPMP22LMNANFKB1MEN1 | |
| Nimustine SCHEMBL124427 | 0.81 | BLM (0.98) | BLMPMP22LMNANFKB1MEN1 | |
| Nimustine SCHEMBL1649348 | 0.80 | BLM (0.96) | BLMPMP22LMNANFKB1MEN1 | |
| Nimustine SCHEMBL1580335 | 0.78 | BLM (0.92) | BLMPMP22LMNANFKB1MEN1 | |
| SCHEMBL6350737 | 0.76 | GAA (0.35) | BLMPMP22MEN1ABCB11ALDH1A1 | |
| Chlorozotocin SCHEMBL6014822 | 0.76 | LMNA (0.54) | BLMPMP22LMNANFKB1 | |
| Chlorozotocin SCHEMBL6051206 | 0.73 | LMNA (0.51) | BLMPMP22LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004045611-A1 | USE OF A THIAZOLIDINEDIONE FOR THE REDUCTION OF SIDE EFFECTS OF CHEMOTHERAPY | N-GENE RESEARCH LABORATORIES INC. (US) | 2004-06-03 | — | — | WO | disclosed |