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Sugi Predict / Compounds / Chlorozotocin

Chlorozotocin

Chlorozotocin

SCHEMBL6014822

CCOP(=O)(OCC)C(C)NC(=O)N(CCCl)N=O.Cc1ncc(CNC(=O)N(CCCl)N=O)c(N)n1.O=NN(CCCl)C(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.54
▸ NFKB1 P19838 1/20 0.54
▸ BLM P54132 1/20 0.54
▸ PMP22 Q01453 1/20 0.54
▸ KDM4E B2RXH2 1/20 0.35
▸ CYP2D6 P10635 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chlorozotocin SCHEMBL6051206 0.97 LMNA (0.51) LMNANFKB1BLMPMP22KDM4E
Chlorozotocin SCHEMBL5512910 0.89 LMNA (0.68) LMNANFKB1BLMPMP22KDM4E
Chlorozotocin SCHEMBL8489015 0.84 LMNA (0.48) LMNABLMPMP22KDM4ECYP2D6
Fotemustine SCHEMBL5508629 0.80 LMNA (0.57) LMNAKDM4ECYP2D6CYP2C19
Nimustine SCHEMBL6912494 0.76 BLM (0.67) LMNANFKB1BLMPMP22
Nimustine SCHEMBL8414 0.73 BLM (1.00) LMNANFKB1BLMPMP22
Ranimustine SCHEMBL3024489 0.73 BLM (0.68) LMNANFKB1BLMPMP22
Nimustine SCHEMBL1649545 0.72 BLM (0.98) LMNANFKB1BLMPMP22
Nimustine SCHEMBL98303 0.72 BLM (0.98) LMNANFKB1BLMPMP22
Nimustine SCHEMBL124427 0.72 BLM (0.98) LMNANFKB1BLMPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006078282-A2 COMPOSITIONS AND SYSTEMS FOR FORMING CROSSLINKED BIOMATERIALS AND ASSOCIATED METHODS OF PREPARATION AND USE ANGIOTECH BIOMATERIALS CORPORATION (US) 2006-07-27 — — WO disclosed
EP-1235598-A2 COMPOSITIONS OF A COMBINATION OF RADIOACTIVE THERAPY AND CELL-CYCLE INHIBITORS Angiotech Pharmaceuticals, Inc. (CA) 2002-09-04 — — EP disclosed
WO-2001036007-A2 COMPOSITIONS OF A COMBINATION OF RADIOACTIVE THERAPY AND CELL-CYCLE INHIBITORS ANGIOTECH PHARMACEUTICALS, INC. (CA) 2001-05-25 — — WO disclosed