SCHEMBL6914022

SCHEMBL6914022

Oc1ccccc1OB(Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Oc1ccccc1O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX1 P51575 3/20 0.39
P2RX4 Q99571 1/20 0.39
P2RX7 Q99572 1/20 0.39
AR P10275 1/20 0.39
CNR1 P21554 1/20 0.35
CNR2 P34972 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
TP53 P04637 1/20 0.35
TSHR P16473 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MAPT P10636 3/20 0.33
TLR8 Q9NR97 1/20 0.33
JAK2 O60674 1/20 0.33
LMNA P02545 1/20 0.33
GAA P10253 1/20 0.33
PTPN2 P17706 1/20 0.33
PTPN1 P18031 1/20 0.33
PTPN6 P29350 1/20 0.33
XBP1 P17861 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL473195 0.79 IDO1 (0.40) TSHRMAPTTLR8ALDH1A1IDO1
SCHEMBL18526886 0.78 MGLL (0.41) P2RX1P2RX4P2RX7ARCNR1
SCHEMBL1276184 0.77 CA2 (0.54) CA1CA2TP53TSHRL3MBTL1
SCHEMBL31457104 0.77 CA2 (0.54) CA1CA2TP53TSHRL3MBTL1
SCHEMBL6914024 0.77 KIF11 (0.42) P2RX1IDO1
SCHEMBL6917535 0.76 NPSR1 (0.42) CA1CA2TP53TSHRMAPT
SCHEMBL8941708 0.71 AR (0.54) ARL3MBTL1MAPTGAANPSR1
SCHEMBL28493928 0.70 TRPV6 (0.42) P2RX1CNR1CNR2TSHRMAPT
SCHEMBL20590990 0.70 CA2 (0.58) CA1CA2TP53TSHRL3MBTL1
SCHEMBL17583792 0.69 IDO1 (0.41) P2RX1CNR1CNR2TSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0971962-B1 CATALYST SYSTEM FOR HIGH YIELD SYNTHESIS OF POLYOLEFINS BP CHEM INT LTD (GB) 2004-02-11 EP disclosed
US-6479599-B1 Catalyst system for high yield synthesis of polyolefins BP CHEMICALS LIMITED (GB) 2002-11-12 US disclosed
EP-0946601-B1 IONIC COMPOUNDS FOR CATALYST COMPONENTS, DISPERSIONS AND SOLID ADDITION POLYMERIZATION CATALYSTS CONTAINING THE SAME DOW GLOBAL TECHNOLOGIES INC (US) 2002-09-25 EP disclosed
US-6166161-A Incorporation of functionalized comonomers in polyolefins THE DOW CHEMICAL COMPANY (US) 2000-12-26 US disclosed
EP-0971962-A1 CATALYST SYSTEM FOR HIGH YIELD SYNTHESIS OF POLYOLEFINS THE DOW CHEMICAL COMPANY (US) 2000-01-19 EP disclosed
EP-0946601-A1 CATALYST COMPONENT DISPERSION COMPRISING AN IONIC COMPOUND AND SOLID ADDITION POLYMERIZATION CATALYSTS CONTAINING THE SAME THE DOW CHEMICAL COMPANY (US) 1999-10-06 EP disclosed
WO-1998045337-A1 CATALYST SYSTEM FOR HIGH YIELD SYNTHESIS OF POLYOLEFINS THE DOW CHEMICAL COMPANY (US) 1998-10-15 WO disclosed
US-5783512-A Catalyst component dispersion comprising an ionic compound and solid addition polymerization catalysts containing the same THE DOW CHEMICAL COMPANY (US) 1998-07-21 US disclosed
WO-1998027119-A1 CATALYST COMPONENT DISPERSION COMPRISING AN IONIC COMPOUND AND SOLID ADDITION POLYMERIZATION CATALYSTS CONTAINING THE SAME THE DOW CHEMICAL COMPANY (US) 1998-06-25 WO disclosed