SCHEMBL6914199

SCHEMBL6914199

CC1=Cc2c(-c3cccc4ccccc34)cccc2C1[Hf](Cl)(Cl)(C1C(C)=Cc2c(-c3cccc4ccccc34)cccc21)=[Si](C)C

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.32
KDM4E B2RXH2 1/20 0.32
MAPT P10636 1/20 0.32
PKM P14618 1/20 0.32
HPGD P15428 1/20 0.32
HSD17B10 Q99714 1/20 0.32
KDM1A O60341 1/20 0.31
CA12 O43570 2/20 0.31
CA1 P00915 2/20 0.31
CA2 P00918 2/20 0.31
CA9 Q16790 2/20 0.31
TRPM2 O94759 1/20 0.30
SLC6A4 P31645 2/20 0.30
CYP2D6 P10635 1/20 0.30
SLC6A2 P23975 1/20 0.30
SLC6A3 Q01959 1/20 0.30
CYP2A6 P11509 2/20 0.30
CYP1A2 P05177 1/20 0.30
DHFR P00374 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7939138 0.88
SCHEMBL7933047 0.86
SCHEMBL17074017 0.85 SMN1; SMN2 (0.32) ALDH1A1MAPTPKMHPGDHSD17B10
SCHEMBL7935517 0.84 NPC1 (0.31) MAPT
SCHEMBL7936604 0.84 SLC6A4 (0.32) KDM4ESLC6A4SLC6A2SLC6A3
SCHEMBL16393655 0.83 HTR1A (0.32) KDM1ASLC6A4SLC6A3
SCHEMBL1201261 0.83 CYP2A6 (0.33) CYP2A6
SCHEMBL5853881 0.82 KDM4E (0.32) ALDH1A1KDM4ECA12CA1CA2
SCHEMBL7933102 0.82 KDM4E (0.32) ALDH1A1KDM4EKDM1ACA12CA1
SCHEMBL818878 0.82 KDM4E (0.34) ALDH1A1KDM4EMAPTCA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040097366-A1 Polyolefin-based composite resin, method for production thereof, catalyst for polymerization of vinly compound and method for polymerization of vinly compound using the same IDEMITSU KOSAN CO. LTD. (JP) 2004-05-20 US disclosed
US-6515037-B2 A molded foam using a copolymer of propylene and an alpha-omega diene having been polymerized in the presence of a metallocene supported catalyst and foaming agent; uniform and fine foamed cells; high foaming magnification; extrusion CHISSO CORPORATION (JP) 2003-02-04 US disclosed
US-6420501-B1 POLYMERIZATION CATALYST ON SUPPORT CHISSO CORPORATION (JP) 2002-07-16 US disclosed
US-6355725-B2 IMPACT STRENGTH, RADIATION TRANSPARENT, GLOSS, TENSILE STRENGTH, ELONGATION CHISSO CORPORATION (JP) 2002-03-12 US disclosed
US-6337372-B1 ADDITIOIN POLYMERIZATION OF OLEFINS AND PROPYLENE FOR BLOCK POLYMERS CHISSO CORPORATION (JP) 2002-01-08 US disclosed
US-20010031834-A1 Using coordination catalyst; flexibility, elasticity; molding materials CHISSO CORPORATION 2001-10-18 US disclosed
US-6303696-B1 MELT TENSION AND FORMABILITY CHISSO CORPORATION (JP) 2001-10-16 US disclosed
US-20010021732-A1 Propylene-ethylene block copolymer compositions and processes for production thereof CHISSO CORPORATION (JP) 2001-09-13 US disclosed
US-20010020045-A1 Polypropylene base resin composition for foam-molding, foamed article using the same composition, production process for the same foamed article and foam-molded product using the foamed-article CHISSO CORPORATION 2001-09-06 US disclosed
US-6211300-B1 CONTROLLING CONCENTRATION CHISSO CORPORATION 2001-04-03 US disclosed
US-6184402-B1 RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES CHISSO CORPORATION (JP) 2001-02-06 US disclosed
US-6153710-A PREPARED BY POLYMERIZING ETHYLENE WITH (A) A TRANSITION METAL COMPOUND AND AN ALUMOXANE, AND IONIC COMPOUND THAT COMPLEXES WITH (A) OR A LEWIS ACID CHISSO CORPORATION (JP) 2000-11-28 US disclosed
EP-1026177-A1 SUPPORTED METALLOCENE CATALYST, PROCESS FOR PREPARING THE SAME, AND PROCESS FOR PRODUCING OLEFIN POLYMERS CHISSO CORPORATION (JP) 2000-08-09 EP disclosed
EP-0942020-A1 POLYPROPYLENE/PROPYLENE-ETHYLENE COPOLYMER COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF CHISSO CORPORATION (JP) 1999-09-15 EP disclosed
EP-0942021-A1 POLYPROPYLENE/PROPYLENE-ETHYLENE COPOLYMER COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF CHISSO CORPORATION (JP) 1999-09-15 EP disclosed
US-5874505-A Polypropylene composition CHISSO CORPORATION (JP) 1999-02-23 US disclosed
EP-0896005-A1 PREACTIVATED CATALYST FOR OLEFIN (CO)POLYMER, CATALYST FOR OLEFIN (CO)POLYMERIZATION, OLEFIN (CO)POLYMER COMPOSITION, AND PROCESS FOR PRODUCING THE SAME CHISSO CORPORATION (JP) 1999-02-10 EP disclosed
EP-0870804-A1 Olefin (co)polymer composition CHISSO CORPORATION (JP) 1998-10-14 EP disclosed