Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 9/20 | 0.52 |
| ▸ | TERT | O14746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10713131 | 0.83 | ACHE (0.50) | ACHETERTMEN1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL11211685 | 0.75 | ATM (0.54) | ACHEMEN1LMNAMAPTKMT2A | |
| SCHEMBL9990610 | 0.75 | ALDH1A1 (0.50) | ACHETERTHIF1AHSD17B10TDP1 | |
| SCHEMBL29464772 | 0.73 | ATM (0.56) | ACHEMEN1LMNAMAPTKMT2A | |
| SCHEMBL278568 | 0.73 | ATM (0.56) | ACHEMEN1LMNAMAPTKMT2A | |
| Hydrochloric Acid SCHEMBL11705198 | 0.72 | CYP3A4 (0.47) | ACHETERTMEN1LMNAMAPT | |
| SCHEMBL2773903 | 0.72 | CYP2A6 (0.48) | ACHEMAPTSMN1; SMN2HTTATM | |
| Iodide SCHEMBL11862696 | 0.71 | ATM (0.54) | ACHEMEN1LMNAMAPTKMT2A | |
| Bromide SCHEMBL11593076 | 0.71 | ATM (0.54) | ACHEMEN1LMNAMAPTKMT2A | |
| Iodide SCHEMBL30211080 | 0.71 | ATM (0.54) | ACHEMEN1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409741-A1 | DETECTION METHOD OF NUCLEIC ACID HYBRIDIZATION | Posco (KR) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003010338-A1 | DETECTION METHOD OF NUCLEIC ACID HYBRIDIZATION | POSCO (KR) | 2003-02-06 | — | — | WO | disclosed |
| EP-0720851-A2 | Medicament for viral inactivation utilizing acridine or acridine derivatives | BEHRINGWERKE Aktiengesellschaft (DE) | 1996-07-10 | — | — | EP | disclosed |
| US-4375510-A | Selective medium composition and method for the detection of Actinomyces viscosus and Actinomyces naeslundii | FORSYTH DENTAL INFIRMARY FOR CHILDREN (US) | 1983-03-01 | — | — | US | disclosed |