Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 7/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11705198 | 0.85 | CYP3A4 (0.47) | ACHECYP3A4ALDH1A1HPGDTSHR | |
| Hydrochloric Acid SCHEMBL6914490 | 0.83 | ACHE (0.52) | ACHECYP3A4HSD17B10LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL11211685 | 0.78 | ATM (0.54) | ACHECYP3A4LMNAKDM4EKMT2A | |
| SCHEMBL2773903 | 0.78 | CYP2A6 (0.48) | ACHEALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL7220429 | 0.78 | ALDH1A1 (0.48) | CYP3A4ALDH1A1HPGDTSHRHSD17B10 | |
| Iodide SCHEMBL3905319 | 0.76 | CYP2A6 (0.47) | ACHEALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL28257139 | 0.76 | CYP1A2 (0.47) | ACHEKMT2ARAB9AMEN1MAPT | |
| SCHEMBL29464772 | 0.76 | ATM (0.56) | ACHECYP3A4LMNAKDM4EKMT2A | |
| SCHEMBL278568 | 0.76 | ATM (0.56) | ACHECYP3A4LMNAKDM4EKMT2A | |
| SCHEMBL9990610 | 0.74 | ALDH1A1 (0.50) | ACHEALDH1A1HPGDTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252278-A2 | Disinfecting agents and their use in disinfecting the skin and mucous membranes | Henkel Kommanditgesellschaft auf Aktien (DE) | 1988-01-13 | — | — | EP | claimed |
| EP-0252278-A2 | Disinfecting agents and their use in disinfecting the skin and mucous membranes | Henkel Kommanditgesellschaft auf Aktien (DE) | 1988-01-13 | — | — | EP | disclosed |