Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7697686 | 0.83 | MEN1 (0.34) | MAPK1MEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL27948803 | 0.71 | CALM1 (0.38) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7195488 | 0.71 | CYP11B1 (0.37) | — | |
| Hydrochloric Acid SCHEMBL29651804 | 0.71 | CYP11B1 (0.37) | — | |
| SCHEMBL4512216 | 0.69 | MEN1 (0.47) | MAPK1MEN1MAPTKMT2AALDH1A1 | |
| Iodide SCHEMBL27933184 | 0.68 | CALM1 (0.38) | — | |
| Fluoride Ion SCHEMBL27933096 | 0.68 | CALM1 (0.38) | — | |
| SCHEMBL7639637 | 0.68 | MAPK1 (0.40) | MAPK1MEN1MAPTKMT2AALDH1A1 | |
| Fluoride Ion SCHEMBL27933167 | 0.68 | CYP11B1 (0.34) | — | |
| Bromide SCHEMBL27933221 | 0.68 | HTR2A (0.34) | MEN1KMT2AHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373337-A2 | PROPYLENE POLYMERS FOR FILMS | Exxonmobil Chemical Patents Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| US-6576306-B2 | Of crystalline isotactic propylene polymer having 0.05 to 15 weight % comonomer units, broad, bimodal molecular weight distribution; made using at least two metallocenes in a sequential or parallel polymerization process | EXXONMOBIL CHEMICAL PATENTS INC. | 2003-06-10 | — | — | US | disclosed |
| WO-2002070572-A2 | PROPYLENE POLYMERS FOR FILMS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2002-09-12 | — | — | WO | disclosed |
| WO-2002070570-A2 | PROPYLENE POLYMERS FOR FILMS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2002-09-12 | — | — | WO | disclosed |
| US-20010039314-A1 | Propylene polymers for films | EXXONMOBIL CHEMICAL PATENTS INC. | 2001-11-08 | — | — | US | disclosed |