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Dideoxy Guanosine Triphosphate

Dideoxy Guanosine Triphosphate

SCHEMBL6915085

Nc1nc2c(ncn2[C@H]2CC[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]1.Nc1ncnc2c1ncn2[C@H]1CC[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O1

nearest known ligand 0.61

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Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.54
▸ P2RX1 P51575 4/20 0.53
▸ P2RX3 P56373 4/20 0.53
▸ P2RX2 Q9UBL9 2/20 0.53
▸ P2RY2 P41231 3/20 0.51
▸ P2RY4 P51582 1/20 0.51
▸ P2RY6 Q15077 1/20 0.51
▸ P2RY1 P47900 3/20 0.51
▸ P2RX4 Q99571 3/20 0.51
▸ SRC P12931 1/20 0.51
▸ ALDH1A1 P00352 1/20 0.51
▸ SMN1; SMN2 Q16637 1/20 0.51
▸ DTYMK P23919 2/20 0.51
▸ RNASEL Q05823 1/20 0.50
▸ TGM2 P21980 1/20 0.49
▸ STING1 Q86WV6 1/20 0.49
▸ POLG P54098 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dideoxy Guanosine Triphosphate SCHEMBL24370775 0.94 POLB (0.60) POLBP2RX3P2RY2P2RY4P2RY6
Dideoxy Guanosine Triphosphate SCHEMBL80109 0.94 POLB (0.60) POLBP2RX3P2RY2P2RY4P2RY6
SCHEMBL18095578 0.94 POLB (0.60) POLBP2RX3P2RY2P2RY4P2RY6
Dideoxy Guanosine Triphosphate SCHEMBL25712486 0.94 POLB (0.60) POLBP2RX3P2RY2P2RY4P2RY6
Dideoxy Guanosine Triphosphate SCHEMBL25720613 0.94 POLB (0.60) POLBP2RX3P2RY2P2RY4P2RY6
SCHEMBL4968018 0.93 POLB (0.61) POLBP2RY2P2RY4P2RY6ALDH1A1
Dideoxy Guanosine Triphosphate SCHEMBL4293277 0.91 POLB (0.61) POLBP2RX1P2RX3P2RX2P2RY2
Dda-Triphosphate SCHEMBL24767736 0.90 P2RX3 (0.63) POLBP2RX1P2RX3P2RX2P2RY2
Dda-Triphosphate SCHEMBL12932305 0.90 P2RX3 (0.63) POLBP2RX1P2RX3P2RX2P2RY2
Dda-Triphosphate SCHEMBL23978346 0.90 P2RX3 (0.63) POLBP2RX1P2RX3P2RX2P2RY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040185466-A1 to detect single nucleotide polymorphisms, genetic mutation, gene expression, forensic identification, disease association, DNA/genomic sequencing and translation/transcription analysis; solid phase synthesis THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK. 2004-09-23 — — US claimed
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