Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9154262 | 0.86 | FFAR3 (0.37) | GRM2GRM3ALDH1A1MEN1CYP1A2 | |
| SCHEMBL10883181 | 0.81 | MEN1 (0.33) | GRM2GRM3ALDH1A1MEN1CYP1A2 | |
| SCHEMBL28767845 | 0.77 | TDP1 (0.36) | ALDH1A1FFAR3TDP1 | |
| SCHEMBL510845 | 0.75 | — | — | |
| SCHEMBL1533575 | 0.73 | CES2 (0.36) | MEN1CYP1A2KMT2A | |
| Bromide SCHEMBL11404129 | 0.72 | — | — | |
| SCHEMBL1408704 | 0.72 | PIN1 (0.42) | ALDH1A1MEN1CYP1A2KMT2ATHRB | |
| SCHEMBL9719160 | 0.72 | ALDH1A1 (0.42) | ALDH1A1MEN1CYP1A2KMT2ATHRB | |
| SCHEMBL1449044 | 0.69 | — | — | |
| SCHEMBL11466197 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105061338-A | 3-methyl-quinoxaline-2-carboxylic acid chemical synthesis method based on ionic liquid system | PINGYUAN WEIFENG YONGZHU TECHNOLOGY CO LTD | 2015-11-18 | — | — | CN | claimed |
| CN-102086169-B | Preparation method of intermediates of Febuxostat | CHONGQING PHARM RES INST CO | 2014-01-15 | — | — | CN | claimed |
| CN-102120733-B | Preparation method of Febuxostat | 2Y CHEM LTD | 2013-11-20 | — | — | CN | claimed |
| CN-102120733-A | Preparation method of Febuxostat | 2Y CHEM LTD | 2011-07-13 | — | — | CN | claimed |
| CN-102086169-A | Preparation method of intermediates of Febuxostat | CHONGQING PHARM RES INST CO | 2011-06-08 | — | — | CN | claimed |
| CN-101391988-B | Method for preparing 2- (4-hydroxyphenyl) -4-methyl-1, 3-thiazole-5-carboxylic acid ethyl ester by one-pot method | NANJING UNIVERSITY OF TECHNOLOGY | 2010-09-08 | — | — | CN | claimed |
| CN-101391988-A | Method for preparing 2- (4-hydroxyphenyl) -4-methyl-1, 3-thiazole-5-carboxylic acid ethyl ester by one-pot method | NANJING UNIVERSITY OF TECHNOLOGY (CN) | 2009-03-25 | — | — | CN | claimed |
| CN-112374994-B | Preparation method of pentafluoroaniline | 衢州学院 | 2022-07-01 | — | — | CN | disclosed |
| CN-112374994-A | Preparation method of pentafluoroaniline | 衢州学院 | 2021-02-19 | — | — | CN | disclosed |
| CN-105924470-B | A kind of bisphosphonate compound and the preparation method and application thereof | 成都云克药业有限责任公司 | 2019-01-29 | — | — | CN | disclosed |
| CN-105524034-B | Preparation, pharmacological action and the application for treating cerebral ischemia of coumarin derivative | 北京大学 | 2018-08-17 | — | — | CN | disclosed |
| CN-105566269-B | Preparation, pharmacological action and the application for treating itch of coumarin derivative | 北京大学 | 2018-07-10 | — | — | CN | disclosed |
| CN-105924470-A | Diphosphoric acid compounds, and preparation method and application thereof | 成都云克药业有限责任公司 | 2016-09-07 | — | — | CN | disclosed |
| EP-0550631-A1 | COMPOUNDS HAVING ANTIHYPERTENSIVE AND ANTI-ISCHEMIC PROPERTIES. | RHONE POULENC RORER INT (US) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005177-A1 | COMPOUNDS HAVING ANTIHYPERTENSIVE AND ANTI-ISCHEMIC PROPERTIES | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-04-02 | — | — | WO | disclosed |
| EP-0183797-B1 | 5-HALO-4H-1,3-DIOXIN-4-ONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE PREPARATION OF ALPHA-HALO-ACETOACETIC ESTERS | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1989-07-19 | — | — | EP | disclosed |
| US-4633013-A | Preparation of α-haloacetoacetic esters | EASTMAN KODAK COMPANY (US) | 1986-12-30 | — | — | US | disclosed |
| EP-0183797-A1 | 5-HALO-4H-1,3-DIOXIN-4-ONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE PREPARATION OF ALPHA-HALO-ACETOACETIC ESTERS. | EASTMAN KODAK CO (US) | 1986-06-11 | — | — | EP | disclosed |
| US-4582913-A | 5-halo-4H-1,3-dioxin-4-one compounds | EASTMAN KODAK COMPANY (US) | 1986-04-15 | — | — | US | disclosed |
| WO-1986000068-A1 | 5-HALO-4H-1,3-DIOXIN-4-ONE COMPOUNDS, alpha-HALO-ACETOACETIC ESTERS PREPARED FROM SUCH COMPOUNDS AND PROCESS FOR THEIR PREPARATION | EASTMAN KODAK COMPANY (DE) | 1986-01-03 | — | — | WO | disclosed |