Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6917587 | 0.91 | TDP1 (0.38) | TDP1ALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL18782617 | 0.86 | TDP1 (0.35) | TDP1ALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL6916433 | 0.85 | GABRP (0.35) | TDP1ALDH1A1HSD17B10LMNACYP3A4 | |
| SCHEMBL9833400 | 0.81 | TDP1 (0.43) | TDP1ALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL888659 | 0.80 | ALDH1A1 (0.50) | TDP1ALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL13300353 | 0.79 | ALDH1A1 (0.46) | TDP1ALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL4892644 | 0.79 | TDP1 (0.42) | TDP1ALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL6911500 | 0.78 | TDP1 (0.38) | TDP1ALDH1A1HSD17B10LMNAHPGD | |
| Cadaverine Tartrate SCHEMBL29546907 | 0.78 | TET2 (0.35) | TDP1LMNACYP3A4USP2MAPT | |
| SCHEMBL13479158 | 0.77 | TDP1 (0.41) | TDP1ALDH1A1HSD17B10LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3270949-A2 | INSULIN ANALOGUES CONTAINING A GLUCOSE-REGULATED CONFORMATIONAL SWITCH | Case Western Reserve University (US) | 2018-01-24 | — | — | EP | claimed |
| CN-107530405-A | Insulin analogs containing glucose-regulated conformational converters | 卡斯西部储备大学 | 2018-01-02 | — | — | CN | claimed |
| WO-2016149222-A2 | INSULIN ANALOGUES CONTAINING A GLUCOSE-REGULATED CONFORMATIONAL SWITCH | CASE WESTERN RESERVE UNIVERSITY (US) | 2016-09-22 | — | — | WO | claimed |
| EP-3270949-B1 | INSULIN ANALOGUES CONTAINING A GLUCOSE-REGULATED CONFORMATIONAL SWITCH | UNIV CASE WESTERN RESERVE (US) | 2025-01-29 | — | — | EP | disclosed |
| US-20240218041-A1 | MOLECULAR DESIGN OF GLUCOSE SENSORS IN GLUCOSE-RESPONSIVE INSULIN ANALOGUES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-07-04 | — | — | US | disclosed |
| US-20230399373-A1 | MOLECULAR DESIGNS OF GLUCOSE-RESPONSIVE AND GLUCOSE-CLEAVABLE INSULIN ANALOGUES | THE TRUSTEES OF INDIANA UNIVERSITY | 2023-12-14 | — | — | US | disclosed |
| WO-2004007418-A1 | A PROCESS FOR THE PREPARATION OF 2-ACETOXYMETHYL-4 HALO-BUT-1-YL ACETATES | RECORDATI S.A. (CH) | 2004-01-22 | — | — | WO | disclosed |
| US-6388074-B2 | Process for the preparation of purine derivatives | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2002-05-14 | — | — | US | disclosed |
| US-20010004668-A1 | Process for the preparation of purine derivatives | BEECHAM GROUP PLC | 2001-06-21 | — | — | US | disclosed |
| US-6187922-B1 | Process for the preparation of purine derivatives | SMITHKLINE BEECHAM PLC (GB) | 2001-02-13 | — | — | US | disclosed |
| EP-0352953-B1 | Process for the preparation of purine derivatives | BEECHAM GROUP PLC (GB) | 2001-01-03 | — | — | EP | disclosed |
| US-5684153-A | Process for the preparation of purine derivatives | BEECHAM GROUP PLC (GB) | 1997-11-04 | — | — | US | disclosed |
| EP-0664294-A1 | Production of nucleoside analogues | Reese, Colin (GB) | 1995-07-26 | — | — | EP | disclosed |
| EP-0641344-A1 | 8-SUBSTITUTED ANTHINES AS PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-08 | — | — | EP | disclosed |
| CN-1094046-A | The xanthine derivative that replaces | SMITHKLINE BEECHAM PLC (GB) | 1994-10-26 | — | — | CN | disclosed |
| WO-1993023401-A1 | 8-SUBSTITUTED ANTHINES AS PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1993-11-25 | — | — | WO | disclosed |
| US-5166198-A | Herpes virus infections | BEECHAM P.L.C. (GB) | 1992-11-24 | — | — | US | disclosed |
| US-5017701-A | Process for the preparation of purine derivatives | BEECHAM GROUP, P.L.C. (GB) | 1991-05-21 | — | — | US | disclosed |
| EP-0404296-A1 | Phosphono derivatives of purine with antiviral activity | Beecham Group p.l.c. (GB) | 1990-12-27 | — | — | EP | disclosed |
| EP-0352953-A2 | Process for the preparation of purine derivatives | BEECHAM GROUP PLC (GB) | 1990-01-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240218041-A1 | MOLECULAR DESIGN OF GLUCOSE SENSORS IN GLUCOSE-RESPONSIVE INSULIN ANALOGUES | IAPP, GPR119, INSR | TDP1 4594/4885ALDH1A1 4558/4885HSD17B10 3085/4885 |
| US-20230399373-A1 | MOLECULAR DESIGNS OF GLUCOSE-RESPONSIVE AND GLUCOSE-CLEAVABLE INSULIN ANALOGUES | IAPP, GPR119, INSR | TDP1 4364/4885ALDH1A1 3714/4885HSD17B10 479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.