Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.52 |
| ▸ | CDC25B | P30305 | 3/20 | 0.52 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.52 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.52 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.52 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9861418 | 0.76 | PDK2 (0.48) | IDO1CDC25BEHMT2PIN1MAOA | |
| SCHEMBL13508801 | 0.76 | CDC25B (0.43) | IDO1CDC25BEHMT2PIN1MAOA | |
| SCHEMBL30229349 | 0.75 | IDO1 (0.46) | IDO1CDC25BEHMT2PIN1MAOA | |
| Naphthoquinone SCHEMBL42139 | 0.71 | IDO1 (1.00) | IDO1CDC25BEHMT2PIN1MAOA | |
| Naphthoquinone SCHEMBL11359780 | 0.71 | IDO1 (1.00) | IDO1CDC25BEHMT2PIN1MAOA | |
| Naphthoquinone SCHEMBL8861335 | 0.71 | IDO1 (1.00) | IDO1CDC25BEHMT2PIN1MAOA | |
| Naphthoquinone SCHEMBL29354680 | 0.71 | IDO1 (1.00) | IDO1CDC25BEHMT2PIN1MAOA | |
| SCHEMBL3673372 | 0.71 | CDC25B (0.41) | IDO1CDC25BEHMT2PIN1MAOA | |
| Naphthoquinone SCHEMBL27807119 | 0.69 | CDC25B (0.82) | IDO1CDC25BEHMT2PIN1MAOA | |
| Naphthoquinone SCHEMBL27995889 | 0.69 | CDC25B (0.82) | IDO1CDC25BEHMT2PIN1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673937-B2 | ANALOGS OF DEOXYPREUSSOMERIN, PALMARUMYCIN CPI AND RELATED NAPHTHOQUINONE SPIROKETALS; INHIBIT THIOREDOXIN-THIOREDOXIN REDUCTASE SYSTEM | THE UNIVERSITY OF PITTSBURGH | 2004-01-06 | — | — | US | disclosed |
| US-20020049221-A1 | Synthesis and methods of use of new antimitotic agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049221-A1 | Synthesis and methods of use of new antimitotic agents | TXNRD1, TXNRD3, TXN2 | IDO1 4538/4885CDC25B 765/4885EHMT2 4656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.