Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214214 | 0.90 | ALDH1A1 (0.43) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL6919835 | 0.88 | L3MBTL1 (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL6820177 | 0.86 | ALDH1A1 (0.42) | ALDH1A1NPC1RAB9ASMN1; SMN2APP | |
| SCHEMBL6921905 | 0.86 | LMNA (0.41) | ALDH1A1RAB9AAPPGAAHCAR3 | |
| SCHEMBL6922174 | 0.85 | MAPT (0.43) | ALDH1A1NPC1RAB9ASMN1; SMN2APP | |
| SCHEMBL6920087 | 0.85 | LMNA (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2APP | |
| SCHEMBL6921251 | 0.82 | TSHR (0.49) | ALDH1A1SMN1; SMN2APPGAAHCAR3 | |
| SCHEMBL6919778 | 0.78 | ALDH1A1 (0.41) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL6920743 | 0.78 | NPC1 (0.42) | ALDH1A1NPC1RAB9ASMN1; SMN2APP | |
| SCHEMBL6916106 | 0.77 | LMNA (0.46) | ALDH1A1SMN1; SMN2APPGAAHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | claimed |
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |