Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6918790 | 0.86 | LMNA (0.42) | LMNAKMT2ATDP1PLOD2MEN1 | |
| SCHEMBL6918282 | 0.85 | ALDH1A1 (0.42) | LMNAKMT2APLOD2NPC1RAB9A | |
| SCHEMBL2214214 | 0.82 | ALDH1A1 (0.43) | LMNATDP1PLOD2GAATSHR | |
| SCHEMBL6921905 | 0.81 | LMNA (0.41) | LMNAKMT2ATDP1PLOD2RAB9A | |
| SCHEMBL6820177 | 0.81 | ALDH1A1 (0.42) | LMNAKMT2APLOD2MEN1NPC1 | |
| SCHEMBL6919835 | 0.81 | L3MBTL1 (0.47) | LMNAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL6916106 | 0.79 | LMNA (0.46) | LMNAKMT2ATDP1PLOD2SMN1; SMN2 | |
| SCHEMBL6921251 | 0.78 | TSHR (0.49) | LMNAKMT2ATDP1PLOD2MEN1 | |
| SCHEMBL6919778 | 0.74 | ALDH1A1 (0.41) | LMNAGAATSHRALDH1A1APP | |
| SCHEMBL6920743 | 0.74 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | claimed |
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |